Self-reports of medication side effects and pain-related activity interference in patients with chronic pain: a longitudinal cohort study

被引：38

作者：

Martel, Marc O. ^{[1
]}

Finan, Patrick H. ^{[2
]}

Dolman, Andrew J. ^{[1
]}

Subramanian, Subu ^{[3
]}

Edwards, Robert R. ^{[1
]}

Wasan, Ajay D. ^{[4
,5
]}

Jamison, Robert N. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Pain Management Ctr,Dept Anesthesiol, Chestnut Hill, MA 02467 USA

[2] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA

[4] Univ Pittsburgh, UPMC Pain Med, Dept Anesthesiol, Pittsburgh, PA USA

[5] Univ Pittsburgh, Dept Psychiat, UPMC Pain Med, Pittsburgh, PA USA

来源：

PAIN | 2015年 / 156卷 / 06期

基金：

加拿大健康研究院;

关键词：

Chronic pain; Medication side effects; Negative affect; Pain-related activity interference; CHRONIC NONCANCER PAIN; CHRONIC OPIOID THERAPY; LOW-BACK-PAIN; PHYSICIANS ASIPP GUIDELINES; SUBSTANCE USE DISORDERS; CLINICAL-TRIALS; NEGATIVE AFFECT; PHARMACOLOGICAL MANAGEMENT; MULTILEVEL MODELS; AMERICAN SOCIETY;

D O I：

10.1097/j.pain.0000000000000154

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The primary purpose of this study was to examine the association between self-reports of medication side effects and pain-related activity interference in patients with chronic pain. The potential moderators of the association between reports of side effects and pain-related activity interference were also examined. A total of 111 patients with chronic musculoskeletal pain were asked to provide, once a month for a period of 6 months, self-reports of medication use and the presence of any perceived side effects (eg, nausea, dizziness, headaches) associated with their medications. At each of thee time points, patients were also asked to provide self-reports of pain intensity, negative affect, and pain-related activity interference. Multilevel modeling analyses revealed that month-to-month increases in perceived medication side effects were associated with heightened pain-related activity interference (P < 0.05). Importantly, multilevel models revealed that perceived medication side effects were associated with heightened pain related activity interference even after controlling for the influence of patient demographics, pain intensity, and negative affect. This study provides preliminary evidence that reports of medication side effects are associated with heightened pain-related activity interference in patients with chronic pain beyond the influence of other pain-relevant variables. The implications of our findings for clinical practice and the management of patients with chronic pain conditions are discussed.

引用

页码：1092 / 1100

页数：9

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