Two New Anti-Tobacco Mosaic Virus Quinoline Alkaloids from the Stems of Nicotiana tabacum

被引：5
作者：
Deng, Le-Le [1 ,2 ,3 ]
Yang, Wen-Wu [1 ]
Jiang, Jia-Rui [1 ]
Xu, Li [1 ]
Zhang, Jian-Duo [1 ]
Liu, Chun-Bo [1 ]
Ling, Jun [1 ]
Kong, Wei-Song [1 ]
Li, Xue-Mei [1 ]
Li, Yin-Ke [1 ]
Liu, Xin [1 ]
Zhou, Tao [1 ,2 ,3 ]
机构：
[1] China Tobacco Yunnan Ind Co Ltd, Technol Ctr, Kunming 650231, Yunnan, Peoples R China
[2] Yunnan Minzu Univ, State Ethn Affairs Commiss, Key Lab Chem Ethn Med Resources, Kunming 650031, Yunnan, Peoples R China
[3] Yunnan Minzu Univ, Minist Educ, Kunming 650031, Yunnan, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2022年 / 58卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Nicotiana tabacum; quinoline alkaloids; anti-tobacco mosaic virus activity; LEAVES; SESQUITERPENES; COUMARINS; TOBACCO;
D O I：
10.1007/s10600-022-03600-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new quinoline alkaloids, 4-acetyl-7-isopropyl-6-methylquinolin-2(1H)-one (1) and 4-acetyl-7-isopropyl-5-methylquinolin-2(1H)-one (2), were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 38.5 and 42.2% at the concentration of 20 mu M, respectively. These rates are higher than that of positive control.
引用
收藏
页码：78 / 81
页数：4
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