Environment and epigenetics

被引：1
作者：
Binder, Elisabeth B. [1 ,2 ]
机构：
[1] Max Planck Inst Psychiat, Abt Translat Forsch Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany
[2] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA
来源：
NERVENARZT | 2019年 / 90卷 / 02期
关键词：
Stress; Trauma; Gene-environment interactions; Mental disorders; Therapeutic interventions; DNA METHYLATION; CHILDHOOD MALTREATMENT; GENE-EXPRESSION; MECHANISMS; DEMETHYLATION; TRANSCRIPTOME; INFLAMMATION; MICRORNAS; RECEPTOR; TRAUMA;
D O I：
10.1007/s00115-018-0657-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Environmental factors are among the strongest risk factors for psychiatric disorders. Differences in exposure to such environments have been associated with lasting biological changes. In recent years epigenetic mechanisms have been brought to the forefront as central in mediating alasting embedding of environmental risk factors. This article first summarizes the different levels of epigenetic regulation and then focuses on mechanisms transducing environmental signals into lasting epigenetic changes. This is followed by examples of how environmentally induced epigenetic changes relate to risk and resilience to psychiatric disorders and their treatment.
引用
收藏
页码：107 / 113
页数：7
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