Optical-resolution Photoacoustic Microscopy of the Metabolic Rate of Oxygen in a Mouse Renal Tumor Model

被引：4

作者：

Yeh, Chenghung ^{[1
]}

Hu, Song ^{[2
]}

Liang, Jinyang ^{[1
]}

Li, Lei ^{[1
]}

Soetikno, Brian ^{[1
]}

Lu, Zhi Hong ^{[3
]}

Sohn, Rebecca E. ^{[3
]}

Maslov, Konstantin ^{[1
]}

Arbeit, Jeffrey M. ^{[3
]}

Wang, Lihong V. ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[2] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22908 USA

[3] Washington Univ, Sch Med, Dept Surg, Div Urol, St Louis, MO 63130 USA

来源：

PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2015 | 2015年 / 9323卷

关键词：

photoacoustic microscopy; optical-resolution; oxygen saturation; tumor; cancer; metabolic rate of oxygen; CEREBRAL-BLOOD-FLOW; TOMOGRAPHY;

D O I：

10.1117/12.2082948

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We propose using noninvasive longitudinal optical-resolution photoacoustic microscopy (L-ORPAM) to quantify blood flow flux, oxygen saturation (sO(2)), and thereby the metabolic rate of oxygen (MRO2), for a renal tumor model in the same mouse over weeks to months. Experiments showed that the sO(2) difference between the artery and vein decreased greatly due to the arteriovenous shunting effect during tumor growth. Moreover, hypermetabolism was exhibited by an increase in MRO2.

引用

页数：8