Optical-resolution Photoacoustic Microscopy of the Metabolic Rate of Oxygen in a Mouse Renal Tumor Model

被引：4

作者：

Yeh, Chenghung ^{[1
]}

Hu, Song ^{[2
]}

Liang, Jinyang ^{[1
]}

Li, Lei ^{[1
]}

Soetikno, Brian ^{[1
]}

Lu, Zhi Hong ^{[3
]}

Sohn, Rebecca E. ^{[3
]}

Maslov, Konstantin ^{[1
]}

Arbeit, Jeffrey M. ^{[3
]}

Wang, Lihong V. ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[2] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22908 USA

[3] Washington Univ, Sch Med, Dept Surg, Div Urol, St Louis, MO 63130 USA

来源：

PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2015 | 2015年 / 9323卷

关键词：

photoacoustic microscopy; optical-resolution; oxygen saturation; tumor; cancer; metabolic rate of oxygen; CEREBRAL-BLOOD-FLOW; TOMOGRAPHY;

D O I：

10.1117/12.2082948

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We propose using noninvasive longitudinal optical-resolution photoacoustic microscopy (L-ORPAM) to quantify blood flow flux, oxygen saturation (sO(2)), and thereby the metabolic rate of oxygen (MRO2), for a renal tumor model in the same mouse over weeks to months. Experiments showed that the sO(2) difference between the artery and vein decreased greatly due to the arteriovenous shunting effect during tumor growth. Moreover, hypermetabolism was exhibited by an increase in MRO2.

引用

页数：8

共 22 条

[1] Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds
An, Lin
Qin, Jia
Wang, Ruikang K.
[J]. OPTICS EXPRESS, 2010, 18 (08): : 8220 - 8228
[2] Laser Doppler imaging of activation-flow coupling in the rat somatosensory cortex
Ances, BM
Greenberg, JH
Detre, JA
[J]. NEUROIMAGE, 1999, 10 (06) : 716 - 723
[3] In vivo flow speed measurement of capillaries by photoacoustic correlation spectroscopy
Chen, Sung-Liang
Xie, Zhixing
Carson, Paul L.
Wang, Xueding
Guo, L. Jay
[J]. OPTICS LETTERS, 2011, 36 (20) : 4017 - 4019
[4] Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia
Culver, JP
Durduran, T
Furuya, T
Cheung, C
Greenberg, JH
Yodh, AG
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (08) : 911 - 924
[5] CORTICAL FUNCTIONAL ARCHITECTURE AND LOCAL COUPLING BETWEEN NEURONAL-ACTIVITY AND THE MICROCIRCULATION REVEALED BY INVIVO HIGH-RESOLUTION OPTICAL IMAGING OF INTRINSIC SIGNALS
FROSTIG, RD
LIEKE, EE
TSO, DY
GRINVALD, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) : 6082 - 6086
[6] Grinvald A., 1986, Functional architecture of cortex revealed by optical imaging of intrinsic signals
[7] Near-infrared optical-resolution photoacoustic microscopy
Hai, Pengfei
Yao, Junjie
Maslov, Konstantin I.
Zhou, Yong
Wang, Lihong V.
[J]. OPTICS LETTERS, 2014, 39 (17) : 5192 - 5195
[8] Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed
Hu, Song
Maslov, Konstantin
Wang, Lihong V.
[J]. OPTICS LETTERS, 2011, 36 (07) : 1134 - 1136
[9] ROLE OF ADENOSINE IN REGULATION OF REGIONAL CEREBRAL BLOOD-FLOW IN SENSORY CORTEX
KO, KR
NGAI, AC
WINN, HR
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (06): : H1703 - H1708
[10] Ngai A. C., 1988, EFFECT SCIATIC NERVE

← 1 2 3 →