Acetylator status and N-acetyltransferase 2 gene polymorphisms; phenotype-genotype correlation with the sulfamethazine test

被引：13

作者：

Taja-Chayeb, Lucia ^{[2
]}

Gonzalez-Fierro, Aurora ^{[2
]}

Miguez-Munoz, Cristian ^{[2
]}

Trejo-Becerril, Catalina ^{[2
]}

de la Cruz-Hernandez, Erick ^{[2
]}

Cantu, David ^{[2
]}

Agundez, Jose A. ^{[3
]}

Vidal-Millan, Silvia ^{[2
]}

Gutierrez, Olga ^{[2
]}

Duenas-Gonzalez, Alfonso ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, INCan, IIB, UBRC, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Basic Res Div, Inst Nacl Cancerol INCan, Lab Epigenet,INCan, Mexico City 04510, DF, Mexico

[3] Univ Extremadura, Sch Med, Dept Pharmacol, Badajoz, Spain

来源：

PHARMACOGENETICS AND GENOMICS | 2011年 / 21卷 / 12期

关键词：

acetylation phenotype; gene polymorphisms; genotype; N-acetyltransferase; 2; SINGLE NUCLEOTIDE POLYMORPHISMS; HUMAN N-ACETYLTRANSFERASE-2; HAPLOTYPE RECONSTRUCTION; EPIGENETIC THERAPY; NAT2; POPULATION; CAFFEINE; PREDICTION; HYDRALAZINE; CONCORDANCE;

D O I：

10.1097/FPC.0b013e32834bec2b

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

N-acetyltransferase 2 (NAT2) catalyzes the bioactivation and/or detoxification of drugs and carcinogens. The aim of this study was to establish the correlation between the NAT2 genotype and the acetylating phenotype in a Mexican population using sulfamethazine as a probe. From a total of 122 individuals, 73 (59.8%) were slow and 49 (40.2%) were fast acetylators. Eleven individuals (9%) had the wild-type genotype (NAT2*4/NAT2*4). The most frequent genotype was NAT2*4/NAT2*5B observed in 20.66% of individuals. In conclusion, our results show that an accurate prediction of the acetylation phenotype by genotyping can be achieved in around half of the population. Further studies with a larger number of individuals are required to establish correlations between phenotype and genotype in half of that patients having a genotype combined with slow/rapid alleles. Pharmacogenetics and Genomics 21:894-901 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：894 / 901

页数：8

共 39 条

[1] Unraveling ambiguous NAT2 genotyping data [J].

Agundez, Jose A. G. ;

Golka, Klaus ;

Martinez, Carmen ;

Selinski, Silvia ;

Blaszkewicz, Meinolf ;

Garcia-Martin, Elena .

CLINICAL CHEMISTRY, 2008, 54 (08) :1390-1394

[2] A Proof-Of-Principle Study of Epigenetic Therapy Added to Neoadjuvant Doxorubicin Cyclophosphamide for Locally Advanced Breast Cancer [J].

Arce, Claudia ;

Perez-Plasencia, Carlos ;

Gonzalez-Fierro, Aurora ;

de la Cruz-Hernandez, Erick ;

Revilla-Vazquez, Alma ;

Chavez-Blanco, Alma ;

Trejo-Becerril, Catalina ;

Perez-Cardenas, Enrique ;

Taja-Chayeb, Lucia ;

Bargallo, Enrique ;

Villarreal, Patricia ;

Ramirez, Teresa ;

Vela, Teresa ;

Candelaria, Myrna ;

Camargo, Maria F. ;

Robles, Elizabeth ;

Duenas-Gonzalez, Alfonso .

PLOS ONE, 2006, 1 (01)

[3] N-acetyltransferase 2 genotyping:: An accurate and feasible approach for simultaneous detection of the most common NAT2 alleles [J].

Brans, R ;

Laizane, D ;

Khan, A ;

Blömeke, B .

CLINICAL CHEMISTRY, 2004, 50 (07) :1264-1266

[4]

Bratton AC, 1939, J BIOL CHEM, V128, P537

[5] A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors [J].

Candelaria, M. ;

Gallardo-Rincon, D. ;

Arce, C. ;

Cetina, L. ;

Aguilar-Ponce, J. L. ;

Arrieta, O. ;

Gonzalez-Fierro, A. ;

Chavez-Blanco, A. ;

de la Cruz-Hernandez, E. ;

Camargo, M. F. ;

Trejo-Becerril, C. ;

Perez-Cardenas, E. ;

Perez-Plasencia, C. ;

Taja-Chayeb, L. ;

Wegman-Ostrosky, T. ;

Revilla-Vazquez, A. ;

Duenas-Gonzalez, A. .

ANNALS OF ONCOLOGY, 2007, 18 (09) :1529-1538

[6]

CASCORBI I, 1995, AM J HUM GENET, V57, P581

[7] Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity [J].

Fuselli, S. ;

Gilman, R. H. ;

Chanock, S. J. ;

Bonatto, S. L. ;

De Stefano, G. ;

Evans, C. A. ;

Labuda, D. ;

Luiselli, D. ;

Salzano, F. M. ;

Soto, G. ;

Vallejo, G. ;

Sajantila, A. ;

Pettener, D. ;

Tarazona-Santos, E. .

PHARMACOGENOMICS JOURNAL, 2007, 7 (02) :144-152

[8] Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms [J].

Garcia-Martin, Elena .

CURRENT DRUG METABOLISM, 2008, 9 (06) :487-497

[9] Pharmacogenetics, drug-metabolizing enzymes, and clinical practice [J].

Gardiner, Sharon J. ;

Begg, Evan J. .

PHARMACOLOGICAL REVIEWS, 2006, 58 (03) :521-590

[10] Reconstruction of N-acetyltransferase 2 haplotypes using PHASE [J].

Golka, Klaus ;

Blaszkewicz, Meinolf ;

Samimi, Mirabutaleb ;

Bolt, Hermann M. ;

Selinski, Silvia .

ARCHIVES OF TOXICOLOGY, 2008, 82 (04) :265-270

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