A convenient synthesis of mono-6-hydroxy permethylated beta-cyclodextrin via tert-butyldimethylsilylation

被引：47

作者：

Chen, Z ^{[1
]}

Bradshaw, JS ^{[1
]}

Lee, ML ^{[1
]}

机构：

[1] BRIGHAM YOUNG UNIV,DEPT CHEM & BIOCHEM,PROVO,UT 84602

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 38期

关键词：

D O I：

10.1016/0040-4039(96)01545-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method to prepare mono-6-hydroxy permethylated beta-cyclodextrin (3) via tert-butyldimethylsilylation is described. Mono-6-tert-butyldimethylsilyl-beta-cyclodextrin was prepared and treated with NaH and CH3I in the same pot. The protecting group was removed by refluxing with NH4F in CH3OH to give 3 in an overall yield of 43%. Copyright (C) 1996 Elsevier Science Ltd

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页码：6831 / 6834

页数：4

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