Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine

被引：18

作者：

Zyuz'kov, G. N. ^{[1
,2
]}

Zhdanov, V. V. ^{[1
]}

Miroshnichenko, L. A. ^{[1
]}

Udut, E. V. ^{[1
]}

Chaikovskii, A. V. ^{[1
]}

Simanina, E. V. ^{[1
]}

Danilets, M. G. ^{[1
]}

Minakova, M. Yu. ^{[1
]}

Udut, V. V. ^{[1
,2
]}

Tolstikova, T. G. ^{[3
]}

Shults, E. E. ^{[3
]}

Stavrova, L. A. ^{[1
]}

Burmina, Ya. V. ^{[1
]}

Dygai, A. M. ^{[1
]}

机构：

[1] ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia

[2] Natl Res Tomsk State Univ, Tomsk, Russia

[3] Russian Acad Sci, Siberian Div, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 159卷 / 01期

关键词：

PI3K; MAPK; alkaloids; progenitor cells; regenerative medicine; FIBROBLAST-GROWTH-FACTOR; PRECURSOR CELLS; HYALURONIDASE; MECHANISMS; REALIZATION; MOBILIZATION; HYPOXIA; STEM;

D O I：

10.1007/s10517-015-2889-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the role of intracellular signaling molecules PI3K, DeDD K ERK1/2, and NEuro38 in stimulation of realization of the growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Inhibitors of PI3K, ERK1/2 and NEuro38 canceled the increase in proliferative activity of progenitor cells, the blockers of ERK1/2 and NEuro38 reduced the intensity of progenitor cell differentiation.

引用

页码：58 / 61

页数：4

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