A new approach for the synthesis of some pyrazolo[5,1-c]triazines and pyrazolo[1,5-a]pyrimidines containing naphtofuran moiety

被引：13

作者：

Abdelhamid, Abdou O. ^{[1
]}

Shokry, Shokry A. ^{[1
]}

Tawfiek, Sayed M. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 49卷 / 01期

关键词：

HYDRAZONOYL HALIDES; INHIBITORS; PYRIDINE; DERIVATIVES; PYRAZOLES; AGENTS; SAR;

D O I：

10.1002/jhet.699

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Naphtho[2,1-b]furan-2-yl)(8-phenylpyrazolo[5,1-c][1,2,4]triazin-3-yl)methanone, ([1,2,4]triazolo[3,4-c][1,2,4]triazin-6-yl)(naphtho[2,1-b]furan-2-yl)methanone, benzo[4,5]imidazo[2,1-c][1,2,4]triazin-3-yl-naphtho[2,1-b]furan-2-yl-methanone, 5-(naphtho[2,1-b]furan-2-yl)pyrazolo[1,5-a]pyrimidine, 7-(naphtho[2,1-b]furan-2-yl)-[1,2,4]triazolo[4,3-a]pyrimidine, 2-naphtho[2,1-b]furan-2-yl-benzo[4,5]imidazo[1,2-a]pyrimidine, pyridine, and pyrazole derivatives are synthesized from sodium salt of 5-hydroxy-1-naphtho[2,1-b]furan-2-ylpropenone and various reagents. The newly synthesized compounds were elucidated by elemental analysis, spectral data, chemical transformation, and alternative synthetic route whenever possible. J. Heterocyclic Chem., (2012).

引用

页码：116 / 124

页数：9

共 25 条

[1] Reactions of hydrazonoyl halides 571:: Reactions of 1-bromo-2-(5-chlorobenzofuranyl)ethanedione-1-phenylhydrazone [J].

Abdelhamid, Abdou O. ;

El-Ghandour, Ahmed H. ;

El-Reedy, Ahmed A. M. .

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2008, 55 (02) :406-413

[2] Reactions of hydrazonoyl halides 54: Synthesis and reactivityof 3-aza-2-bromo-1-(3-oxobenzo[f]chromen-2-yl-3-(arylamino)prop-2-en-1-one [J].

Abdelhamid, Abdou O. ;

Abdelaziz, Hassen M. .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2007, 182 (12) :2791-2800

[3] Reaction of hydrazonoyl halides 51:: A facile synthesis of 5-arylthiazoles and triazolino[4,3-a]pyrimidines as antimicrobial agents [J].

Abdelhamid, Abdou O. ;

Sayed, Abdelwahed R. ;

Zaki, Yasser H. .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2007, 182 (07) :1447-1457

[4] Convenient Synthesis of Some New Pyrazolo[1,5-a]pyrimidine, Pyridine, Thieno[2,3-b]pyridine, and Isoxazolo[3,4-d]pyridazine Derivatives Containing Benzofuran Moiety [J].

Abdelhamid, Abdou O. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 46 (04) :680-686

[5] Reactions of hydrazonoyl halides 43:: Synthesis of some new 2,3-dihydro-1,3,4-thiadiazoles, pyrazoles, pyrazolo[3,4-d]-pyridazines, thieno[2,3-b]pyridines, pyrimidino[4′,5′:4,5]thieno[2,3-b]pyridines and pyrrolo[3,4-d]pyrazoles [J].

Abdelhamid, AO ;

Alkhodshi, MAM .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2005, 42 (04) :527-533

[6]

Abu Elmaati TM, 2002, ACTA CHIM SLOV, V49, P721

[7] Synthesis of some pyrazolopyrimidines as purine analogues [J].

Ahmed, Sayed A. ;

Hussein, Ahmed M. ;

Hozayen, Walaa G. M. ;

El-Ghandour, Ahmed H. H. ;

Abdelhamid, Abdou O. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2007, 44 (04) :803-810

[8] REACTION OF BETA-AMINOCROTONITRILE AND ALPHA-FORMYL PHENYLACETONITRILE WITH HYDRAZINE - SYNTHESIS OF 7-AMINO-[1,5-A]PYRAZOLOPYRIMIDINES [J].

ALCALDE, E ;

MENDOZA, JD ;

GARCIAMA.JM ;

ALMERA, C ;

ELGUERO, J .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1974, 11 (03) :423-429

[9] Synthesis and SAR of a new series of COX-2-selective inhibitors:: Pyrazolo[1,5-α]pyrimidines [J].

Almansa, C ;

de Arriba, AF ;

Cavalcanti, FL ;

Gómez, LA ;

Miralles, A ;

Merlos, M ;

García-Rafanell, J ;

Forn, J .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (03) :350-361

[10] A mild and efficient method for the preparation of 3-(2'-aminoaryl)pyrazoles from 4-chloroquinolines [J].

Borges, Julio C. ;

de Oliveira, Cesar D. ;

Pinheiro, Luiz C. da Silva ;

Marra, Roberta K. F. ;

Khan, Misbahul Ain ;

Wardell, James L. ;

Wardell, Solange M. S. V. ;

Bernardino, Alice M. R. .

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2007, 18 (08) :1571-1574

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