Development and validation of a novel strong prognostic index for colon cancer through a robust combination of laboratory features for systemic inflammation: a prognostic immune nutritional index

被引：35

作者：

Jung, Sang-Hyuk ^{[1
,2
]}

Hao, Jie ^{[1
]}

Shivakumar, Manu ^{[1
]}

Nam, Yonghyun ^{[1
]}

Kim, Jaesik ^{[3
]}

Kim, Min Jung ^{[4
,5
]}

Ryoo, Seung-Bum ^{[4
,5
]}

Choe, Eun Kyung ^{[1
,4
,6
]}

Jeong, Seung-Yong ^{[4
,5
]}

Park, Kyu Joo ^{[4
]}

Park, Sung Chan ^{[7
]}

Sohn, Dae Kyung ^{[7
]}

Oh, Jae Hwan ^{[7
]}

Won, Hong-Hee ^{[2
,8
]}

Kim, Dokyoon ^{[1
,9
]}

Park, Ji Won ^{[1
,4
,5
]}

机构：

[1] Univ Penn, Dept Biostat Epidemiol & Informat, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Sungkyunkwan Univ, Samsung Med Ctr, Dept Digital Hlth, SAIHST, Seoul, South Korea

[3] Ajou Univ, Dept Comp Engn, Suwon, South Korea

[4] Seoul Natl Univ, Dept Surg, Coll Med, Seoul, South Korea

[5] Seoul Natl Univ, Canc Res Inst, Coll Med, Seoul, South Korea

[6] Seoul Natl Univ Hosp, Healthcare Res Inst, Healthcare Syst Gangnam Ctr, Seoul, South Korea

[7] Natl Canc Ctr, Ctr Colorectal Canc, Goyang, South Korea

[8] Sungkyunkwan Univ, Samsung Med Ctr, Samsung Adv Inst Hlth Sci & Technol SAIHST, Seoul, South Korea

[9] Univ Penn, Inst Biomed Informat, Philadelphia, PA 19104 USA

来源：

BRITISH JOURNAL OF CANCER | 2022年 / 126卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

COLORECTAL-CANCER; SERUM-ALBUMIN; SURVIVAL; RATIO;

D O I：

10.1038/s41416-022-01767-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Systemic inflammation is associated with survival outcomes in colon cancer. However, it is not well-known which systemic inflammatory marker is a powerful prognostic marker in patients with colon cancer. Methods A total of 4535 colon cancer patients were included in this study. We developed a novel prognostic index using a robust combination of seven systemic inflammation-associated blood features of the discovery set. The predictability and generality of the novel prognostic index were evaluated in the discovery, validation and replication sets. Results Among all combinations, the combination of albumin and monocyte count was the best candidate expression. The final formula of the proposed novel index is named the Prognostic Immune and Nutritional Index (PINI). The concordance index of PINI for overall and progression-free survival was the highest in the discovery, validation and replication sets compared to existing prognostic inflammatory markers. PINI was found to be a significant independent prognostic factor for both overall and progression-free survival. Conclusions PINI is a novel prognostic index that has improved discriminatory power in colon cancer patients and appears to be superior to existing prognostic inflammatory markers. PINI can be utilised for decision-making regarding personalised treatment as the complement of the TNM staging system.

引用

页码：1539 / 1547

页数：9

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