The caulindoles:: dimeric prenylindoles from Isolona cauliflora

被引：29

作者：

Makangara, JJ ^{[1
]}

Henry, L ^{[1
]}

Jonker, SA ^{[1
]}

Nkunya, MHH ^{[1
]}

机构：

[1] Univ Dar Es Salaam, Dept Chem, Dar Es Salaam, Tanzania

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 02期

关键词：

Isolona cauliflora; Annonaceae; prenylindoles; caulindoles; antifungals;

D O I：

10.1016/j.phytochem.2003.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four dimeric prenylindoles occurring in diastereomeric pairs, the caulindole A-D, 5-(3-methyl-2-butenyl)-1H-indole, and (E)-5-(3-methylbuta-1,3-dienyl)-1H-indole were isolated from the stem and root barks of Isolona cauliflora, an ecologically endangered Annonaceae species. Structural determination was achieved based on interpretation of spectroscopic data. Biogenetically, the caulindoles are considered as Diels-Alder-type cycloaddition products of mono- and/or bis-prenylindoles [e.g. 5-(3-methyl-2-butenyl)-1H-indole and (E)-5-(3-methylbuta-1,3-dienyl)-1H-indole] as the dienes and dienophiles. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：227 / 232

页数：6

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