Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy

被引：454

作者：

Wang, Liming ^{[2
]}

Liu, Ying ^{[2
]}

Li, Wei ^{[3
,4
]}

Jiang, Xiumei ^{[2
]}

Ji, Yinglu ^{[1
]}

Wu, Xiaochun ^{[1
]}

Xu, Ligeng ^{[2
]}

Qiu, Yang ^{[2
]}

Zhao, Kai ^{[5
]}

Wei, Taotao ^{[5
]}

Li, Yufeng ^{[3
,4
]}

Zhao, Yuliang ^{[3
,4
]}

Chen, Chunying ^{[2
,3
,4
]}

机构：

[1] Natl Ctr Nanosci & Technol China, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China

[2] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[3] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

[4] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China

[5] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China

来源：

NANO LETTERS | 2011年 / 11卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Gold nanorods; serum proteins; uptake and removal; intracellular localization; mitochondrion-targeted nanomaterials; tumor therapy; CELLULAR UPTAKE; POLYCATIONIC POLYMERS; SURFACE-CHEMISTRY; IN-VIVO; NANOPARTICLES; NANOSTRUCTURES; ENDOCYTOSIS; EXOCYTOSIS; MECHANISM; TOXICITY;

D O I：

10.1021/nl103992v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have observed that Au nanorods (NRs) have distinct effects on cell viability via killing cancer cells while posing negligible impact on normal cells and mesenchymal stem cells. Obvious differences in cellular uptake, intracellular trafficking, and susceptibility of lysosome to Au NRs by different types of cells resulted in selective accumulation of Au NRs in the mitochondria of cancer cells. Their long-term retention decreased mitochondrial membrane potential and increased reactive oxygen species level that enhances the likelihood of cell death. These findings thus provide guidance for the design of organelle-targeted nanomaterials in tumor therapy.

引用

页码：772 / 780

页数：9

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