Nuclear and unclear functions of SUMO

被引：568
作者：
Seeler, JS [1 ]
Dejean, A [1 ]
机构：
[1] Inst Pasteur, INSERM, Nucl Org & Oncogenesis Unit, F-75724 Paris 15, France
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 09期
关键词：
D O I：
10.1038/nrm1200
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleate cells, including the control of nucleocytoplasmic signalling and transport and the faithful replication of a large and complex genome, as well as the regulation of gene expression.
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页码：690 / 699
页数：10
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