Loganin exerts a protective effect on ischemia-reperfusion-induced acute kidney injury by regulating JAK2/STAT3 and Nrf2/HO-1 signaling pathways

被引：11
作者：
Huang, Fei [1 ]
Wang, Xiang [2 ]
Xiao, Guifang [1 ]
Xiao, Juan [1 ]
机构：
[1] Peoples Hosp Jianshi Cty, Dept Nephrol, Enshi Autonomous, Hubei, Peoples R China
[2] Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Dept Nephrol, 158 Wuyang St, Enshi Autonomous, Hubei, Peoples R China
来源：
DRUG DEVELOPMENT RESEARCH | 2022年 / 83卷 / 01期
关键词：
acute kidney injury; JAK2; STAT3; loganin; Nrf2; HO-1; IRIDOID GLYCOSIDE; OXIDATIVE STRESS; CORNI FRUCTUS; INFLAMMATION; TRANSPLANTATION; APOPTOSIS; SYSTEM; LIVER; RATS;
D O I：
10.1002/ddr.21853
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To investigate the role of loganin in hypoxia/reperfusion (H/R)-induced renal tubular epithelial cells and ischemia/reperfusion-induced acute kidney injury (AKI). Cells were received H/R treatment and cultured with different concentrations of loganin. The cell activity and apoptosis were detected. The expressions of apoptosis-related proteins, inflammatory factors, oxidative stress related molecules, and related molecules of JAK2/STAT3 and Nrf2/HO-1 signaling pathways were measured. AKI model of mice was established by I/R procedure, and the kidney was collected for hematoxylin and eosin (HE) staining. H/R treatment inhibited cell activity and apoptosis, but loganin attenuated the effect of H/R. Moreover, loganin inhibited H/R-induced inflammatory response and oxidative stress in tubular epithelial cells. Loganin down-regulated the expression of apoptosis-related proteins, suppressed JAK2/STAT3 pathway, and activated Nrf2/HO-1 pathway. In animal experiment, loganin reduced tubular injury in AKI mice.Loganin had anti-apoptotic, anti-inflammatory, and anti-oxidative stress effects on H/R-induced tubular epithelial cells, and could improve AKI in mice induced by I/R. This effect might be achieved by inhibiting JAK2/STAT3 and activating the Nrf2/HO-1 signaling pathway.
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收藏
页码：150 / 157
页数：8
相关论文
共 38 条
[1]  
Chen WD, 2019, EUR REV MED PHARMACO, V23, P1770, DOI 10.26355/eurrev_201902_17139
[2]   Loganin alleviates testicular damage and germ cell apoptosis induced by AGEs upon diabetes mellitus by suppressing the RAGE/p38MAPK/NF-κB pathway [J].
Chen, Yuping ;
Jiao, Ni ;
Jiang, Ming ;
Liu, Liping ;
Zhu, Yihui ;
Wu, Hongyan ;
Chen, Jing ;
Fu, Yingxue ;
Du, Qiu ;
Xu, Huiqin ;
Sun, Jihu .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (11) :6083-6095
[3]   Loganin and catalpol exert cooperative ameliorating effects on podocyte apoptosis upon diabetic nephropathy by targeting AGEs-RAGE signaling [J].
Chen, Yuping ;
Chen, Jing ;
Jiang, Ming ;
Fu, Yingxue ;
Zhu, Yihui ;
Jiao, Ni ;
Liu, Liping ;
Du, Qiu ;
Wu, Hongyan ;
Xu, Huiqin ;
Sun, Jihu .
LIFE SCIENCES, 2020, 252
[4]   Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury [J].
Diao, Changhui ;
Chen, Zhiyuan ;
Qiu, Tao ;
Liu, Hao ;
Yang, Yuanyuan ;
Liu, Xiuheng ;
Wu, Junfeng ;
Wang, Lei .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, 2019
[5]   Acute Kidney Injury [J].
Farrar, Ashley .
NURSING CLINICS OF NORTH AMERICA, 2018, 53 (04) :499-+
[6]   Methane Alleviates Acetaminophen-Induced Liver Injury by Inhibiting Inflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Apoptosis through the Nrf2/HO-1/NQO1 Signaling Pathway [J].
Feng, Yang ;
Cui, Ruixia ;
Li, Zeyu ;
Zhang, Xia ;
Jia, Yifan ;
Zhang, Xing ;
Shi, Jinghong ;
Qu, Kai ;
Liu, Chang ;
Zhang, Jingyao .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, 2019
[7]   STAT3: a multifaceted oncoprotein [J].
Guanizo, Aleks C. ;
Fernando, Chamira Dilanka ;
Garama, Daniel J. ;
Gough, Daniel J. .
GROWTH FACTORS, 2018, 36 (1-2) :1-14
[8]   Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes [J].
Hu, Jiaming ;
Zhou, Jinyi ;
Wu, Jinting ;
Chen, Quan ;
Du, Weibin ;
Fu, Fangda ;
Yu, Huan ;
Yao, Sai ;
Jin, Hongting ;
Tong, Peijian ;
Chen, Di ;
Wu, Chengliang ;
Ruan, Hongfeng .
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 247
[9]   STAT3: A Potential Drug Target for Tumor and Inflammation [J].
Hu, Yang Sheng ;
Han, Xu ;
Liu, Xin Hua .
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2019, 19 (15) :1305-1317
[10]   Emerging Role of Ferroptosis in Acute Kidney Injury [J].
Hu, Zhaoxin ;
Zhang, Hao ;
Yang, Shi-kun ;
Wu, Xueqin ;
He, Dong ;
Cao, Ke ;
Zhang, Wei .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, 2019
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