Targeted Therapies in the Treatment of Sarcomas

被引：6

作者：

Hoffner, Brianna ^{[1
]}

Elias, Anthony D. ^{[1
]}

Villalobos, Victor M. ^{[1
]}

机构：

[1] Univ Colorado, Sch Med, Dept Med, Div Med Oncol, 1665 Aurora Court,Anschutz Canc Pavil Rm 5310, Aurora, CO 80045 USA

来源：

TARGETED ONCOLOGY | 2018年 / 13卷 / 05期

关键词：

GASTROINTESTINAL STROMAL TUMORS; SOFT-TISSUE SARCOMA; GIANT-CELL TUMOR; PHASE-I; LOCAL RECURRENCE; OPEN-LABEL; IMATINIB; BONE; EFFICACY; SAFETY;

D O I：

10.1007/s11523-018-0583-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

About 50% of sarcomas have specific pathology-defining molecular alterations including mutations, fusion genes, and gene amplifications. Some of these alterations appear to be oncogenic drivers, and a subset can be utilized as targets for standard or experimental molecularly targeted agents in the clinic. In addition, immunotherapies may have a growing role in the treatment of sarcomas in the future.

引用

页码：557 / 565

页数：9

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