Advances on Natural Abietane, Labdane and Clerodane Diterpenes as Anti-Cancer Agents: Sources and Mechanisms of Action

被引：26

作者：

Acquaviva, Rosaria ^{[1
,2
]}

Malfa, Giuseppe A. ^{[1
,2
]}

Loizzo, Monica R. ^{[3
]}

Xiao, Jianbo ^{[4
]}

Bianchi, Simone ^{[1
]}

Tundis, Rosa ^{[3
]}

机构：

[1] Univ Catania, Dept Drug & Hlth Sci, Viale A Doria, I-95125 Catania, Italy

[2] Univ Catania, Res Ctr Nutraceut & Hlth Prod, Dept Drug & Hlth Sci, CERNUT, Viale A Doria, I-95125 Catania, Italy

[3] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy

[4] Univ Vigo, Fac Sci, Dept Analyt & Food Chem, Nutr & Bromatol Grp, Orense 32004, Spain

来源：

MOLECULES | 2022年 / 27卷 / 15期

关键词：

plant secondary metabolites; phytochemicals; terpenoids; tumor; cytotoxicity; apoptosis; CANCER-CELL-PROLIFERATION; MITOCHONDRIAL-MEDIATED APOPTOSIS; ANDROGRAPHOLIDE INDUCES APOPTOSIS; TANSHINONE-IIA; DOWN-REGULATION; COLON-CANCER; CARNOSIC ACID; IN-VITRO; BIOLOGICAL-ACTIVITY; COLORECTAL-CANCER;

D O I：

10.3390/molecules27154791

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extensive research over the past decades has identified numerous phytochemicals that could represent an important source of anti-cancer compounds. There is an immediate need for less toxic and more effective preventive and therapeutic strategies for the treatment of cancer. Natural compounds are considered suitable candidates for the development of new anti-cancer drugs due to their pleiotropic actions on target events with multiple manners. This comprehensive review highlighted the most relevant findings achieved in the screening of phytochemicals for anticancer drug development, particularly focused on a promising class of phytochemicals such as diterpenes with abietane, clerodane, and labdane skeleton. The chemical structure of these compounds, their main natural sources, and mechanisms of action were critically discussed.

引用

页数：29

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[71] NETO2 promotes pancreatic cancer cell proliferation, invasion and migration via activation of the STAT3 signaling pathway [J].