Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches

被引：64

作者：

Berridge, Michael V. ^{[1
]}

McConnell, Melanie J. ^{[2
]}

Grasso, Carole ^{[1
]}

Bajzikova, Martina ^{[3
]}

Kovarova, Jaromira ^{[3
]}

Neuzil, Jiri ^{[3
,4
,5
]}

机构：

[1] Malaghan Inst Med Res, Canc Cell & Mol Biol Grp, Wellington 6012, New Zealand

[2] Victoria Univ Wellington, Biol Sci, Wellington 6012, New Zealand

[3] Acad Sci Czech Republ, Inst Biotechnol, Mol Therapy Grp, Prague 14220, Czech Republic

[4] Griffith Univ, Mitochondria Apoptosis & Canc Res Grp, Sch Med Sci, Southport, Qld 4222, Australia

[5] Griffith Univ, Griffith Hlth Inst, Southport, Qld 4222, Australia

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2016年 / 38卷

基金：

澳大利亚研究理事会;

关键词：

MESENCHYMAL STEM-CELLS; SUPPORTING ASPARTATE BIOSYNTHESIS; TUNNELING NANOTUBES; GENE-TRANSFER; CANCER-CELLS; PYRUVATE CARBOXYLATION; MEMBRANE NANOTUBES; ENDOTHELIAL-CELLS; STROMAL CELLS; TRANSPORT;

D O I：

10.1016/j.gde.2016.04.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Current dogma holds that genes are the property of individual mammalian cells and partition between daughter cells during cell division. However, and rather unexpectedly, recent research has demonstrated horizontal cell-to-cell transfer of mitochondria and mitochondrial DNA in several mammalian cell culture systems. Furthermore, unequivocal evidence that mitochondrial DNA transfer occurs in vivo has now been published. While these studies show horizontal transfer of mitochondrial DNA in pathological settings, it is also possible that intercellular mitochondrial transfer is a fundamental physiological process with a role in development and tissue homeostasis.

引用

页码：75 / 82

页数：8

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