Biomarkers for colitis-associated colorectal cancer

被引：28

作者：

Chen, Ru ^{[1
]}

Lai, Lisa A. ^{[1
]}

Brentnall, Teresa A. ^{[1
]}

Pan, Sheng ^{[1
]}

机构：

[1] Univ Washington, Dept Med, 1959 NE Pacific St, Seattle, WA 98195 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 35期

关键词：

Biomarker; Colitis; Dysplasia; Colorectal cancer; Surveillance; Progressor; Non-progressor; INFLAMMATORY-BOWEL-DISEASE; CHRONIC ULCERATIVE-COLITIS; NEOPLASTIC PROGRESSION; NONNEOPLASTIC MUCOSA; CHROMOSOMAL INSTABILITY; CLONAL EXPANSIONS; OXIDATIVE STRESS; SHORT TELOMERES; COLON-CANCER; DNA-DAMAGE;

D O I：

10.3748/wjg.v22.i35.7882

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Patients with extensive ulcerative colitis (UC) of more than eight years duration have an increased risk of colorectal cancer. Molecular biomarkers for dysplasia and cancer could have a great clinical value in managing cancer risk in these UC patients. Using a wide range of molecular techniques - including cutting-edge OMICS technologies - recent studies have identified clinically relevant biomarker candidates from a variety of biosamples, including colonic biopsies, blood, stool, and urine. While the challenge remains to validate these candidate biomarkers in multi-center studies and with larger patient cohorts, it is certain that accurate biomarkers of colitis-associated neoplasia would improve clinical management of neoplastic risk in UC patients. This review highlights the ongoing avenues of research in biomarker development for colitis-associated colorectal cancer.

引用

页码：7882 / 7891

页数：10

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