The Roles of B Cells and Their Interactions with Fibroblast-Like Synoviocytes in the Pathogenesis of Rheumatoid Arthritis

被引：32
|
作者：
Wang, Qingtong [1 ]
Ma, Yukun [1 ]
Liu, Dandan [1 ]
Zhang, Lingling [1 ]
Wei, Wei [1 ]
机构：
[1] Anhui Med Univ, Inst Clin Pharmacol, Educ Minist, Key Lab Antiinflammatory & Immunopharmacol, Hefei 230032, Anhui, Peoples R China
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2011年 / 155卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Rheumatoid arthritis; Fibroblast-like synoviocyte; B cells; Cell contact; TUMOR-NECROSIS-FACTOR; CITRULLINATED PEPTIDE ANTIBODIES; T-CELLS; DENDRITIC CELLS; GERMINAL CENTER; FACTOR FAMILY; GROWTH-FACTOR; TNF FAMILY; MIGRATION; CHEMOKINE;
D O I：
10.1159/000321185
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that may affect many tissues and organs but principally attacks synovial joints. The pathogenesis of RA is complex and encompasses many cell types, including T cells, B cells and fibroblast-like synoviocytes (FLSs); each is believed to play a significant role in the process of RA. Interactions between T cells and B cells and between T cells and FLSs have been studied in depth. However, it has been showed that B cells also play a critical role in rheumatoid synovitis. Therefore, cell-cell contact between B cells and FLSs may be significant in the pathophysiology of RA. This review focuses on recent advances in the research of the interaction between B cells and FLSs. Considering this interaction may provide directions for innovations in RA therapy. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码：205 / 211
页数：7
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