PARTICLE MASS DITRIBUTION IN BATCH FLUIDIZED BED COATING PROCESS

被引:1
作者
Lipin, A. G. [1 ]
Lipin, A. A. [1 ]
机构
[1] Ivanovo State Univ Chem & Technol, Dept Proc & Apparat Chem Technol, Sheremetevskiy Ave 7, Ivanovo 153000, Russia
来源
IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA | 2021年 / 64卷 / 12期
关键词
modeling; encapsulation; coating variability; fluidized bed; ENCAPSULATION; VARIABILITY; SIMULATION; DEM; MODEL;
D O I
10.6060/ivkkt.20216412.6448
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The paper deals with mathematical modeling the coating process of particulate materials. Inter-particle coating variability is one of the main indicators of the encapsulated product quality. The function of particle distribution according to the mass of coverage was shown can be used to characterize the inter-particle coating variability when the thick shells are applied. The paper presents a mathematical model of the batch fluidized bed coating. The model allows predicting the function of particle distribution according to the mass of coverage. The model bases on the population balance equations, derived for the two compartments: a spraying zone and a drying zone. An algorithm for the numerical solution of the function of particle distribution according to the mass of coverage is described. The influences of the main process parameters on the coating uniformity are shown. As the growth rate of the coating mass decreases, the coating variability of the particles decreases too. This is achieved by reducing the flow rate of the coating solution sprayed by the nozzle. As the flow rate of particles through the spraying zone decreases, the coating variability increases at a fixed processing time. The coating variability value CV was proposed for assessment of the coating substance distribution over the encapsulated particles. The simulation results showed a decrease in the CV value during the process, which indicates a decrease in the ununiformity distribution of the mass of the film-forming substance between the particles at the selected process parameters.
引用
收藏
页码:84 / 90
页数:7
相关论文
共 26 条
[11]   SIMULATION OF HEAT AND MASS TRANSFER PROCESSES UNDER GRANULES CAPSULATION IN FLUIDIZED BED [J].
Lipin, A. A. ;
Nebukin, V. O. ;
Lipin, A. G. .
IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA, 2018, 61 (4-5) :98-104
[12]  
Lipin AG, 2019, IZV VUZ KHIM KH TEKH, V62, P84, DOI [10.6060/ivkkt.20196205.5793, 10.6060/ivkkt201962fp.5793]
[13]  
Lipin A.G., 2017, SOVREMENNYE NAUKOEMK, P86
[14]   Simulation of pellet coating in Wurster coaters [J].
Norouzi, Hamid Reza .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 590
[15]   Asymptotic limits on tablet coating variability based on cap-to-band thickness distributions: A discrete element model (DEM) study [J].
Pei, Chunlei ;
Elliott, James A. .
CHEMICAL ENGINEERING SCIENCE, 2017, 172 :286-296
[16]   An overview of encapsulation of active compounds used in food products by drying technology [J].
Ray, Sohini ;
Raychaudhuri, Utpal ;
Chakraborty, Runu .
FOOD BIOSCIENCE, 2016, 13 :76-83
[17]   Stochastic modelling of particle coating in fluidized beds [J].
Rieck, Christian ;
Bueck, Andreas ;
Tsotsas, Evangelos .
NEW PARADIGM OF PARTICLE SCIENCE AND TECHNOLOGY, PROCEEDINGS OF THE 7TH WORLD CONGRESS ON PARTICLE TECHNOLOGY, 2015, 102 :996-1005
[18]   Experiments and numerical modeling to estimate the coating variability in a pan coater [J].
Sahni, Ekneet ;
Chaudhuri, Bodhisattwa .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 418 (02) :286-296
[19]   Pharmaceutical Application of Tablet Film Coating [J].
Seo, Ki-Soo ;
Bajracharya, Rajiv ;
Lee, Sang Hoon ;
Han, Hyo-Kyung .
PHARMACEUTICS, 2020, 12 (09) :1-20
[20]   An analysis of the mini-tablet fluidized bed coating process [J].
Sibanc, Rok ;
Turk, Magdalena ;
Dreu, Rok .
CHEMICAL ENGINEERING RESEARCH & DESIGN, 2018, 134 :15-25