Aggregation and spread of synuclein in Parkinson's disease

被引：5

作者：

Bezard, Erwan ^{[1
]}

Dehay, Benjamin ^{[1
]}

机构：

[1] Univ Bordeaux, CNRS, IMN Inst Malad Neurodegenerat, UMR 5293, F-33000 Bordeaux, France

来源：

M S-MEDECINE SCIENCES | 2022年 / 38卷 / 01期

关键词：

ALPHA-SYNUCLEIN; LEWY BODIES; PATHOLOGY; NEURONS;

D O I：

10.1051/medsci/2021241

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The vast majority of neurodegenerative diseases are associated with an accumulation of undegraded and aggregated proteins. Hence the word proteinopathies is now used to refer to these neurodegenerative diseases. The synucleinopathies are one component of them, in particular in Parkinson's disease. The neuropathological features of Parkinson's disease are the progressive loss of dopamine neurons in the midbrain and the formation of aggregates composed mainly of a-synuclein protein. Experimental evidence suggests that under pathological conditions, normal soluble a-synuclein protein adopts an abnormal folding and subsequently aggregates, with a propensity to spread throughout the central nervous system. This review article discusses the specifics of a-synuclein aggregation and emerging mechanisms for understanding its spread and aims at providing a molecular explanation for the progression of the disease in humans.

引用

页码：45 / 51

页数：7

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