RREB1 Integrates TGF-β and RAS Signals to Drive EMT

被引：10
作者：
Fattet, Laurent [1 ]
Yang, Jing [1 ]
机构：
[1] Univ Calif San Diego, Dept Pharmacol, Moores Canc Ctr, 3855 Hlth Sci Dr, La Jolla, CA 92093 USA
来源：
DEVELOPMENTAL CELL | 2020年 / 52卷 / 03期
关键词：
PLASTICITY; GROWTH;
D O I：
10.1016/j.devcel.2020.01.020
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
TGF-beta is long known to require Ras activation to induce EMT. In a recent issue of Nature, Massague and colleagues (Su et al., 2020) identify RAS-responsive element binding protein 1 (RREB1) as a critical integrator of TGF-beta and Ras signals during both developmental and cancer EMT programs.
引用
收藏
页码：259 / 260
页数：2
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