Arabidopsis relatives of the human lysine-specific demethylase1 repress the expression of FWA and FLOWERING LOCUS C and thus promote the floral transition

被引：204
作者：
Jiang, Danhua
Yang, Wannian
He, Yuehui [1 ]
Amasino, Richard M.
机构：
[1] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore
[2] Temasek Life Sci Lab, Singapore 117604, Singapore
[3] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
来源：
PLANT CELL | 2007年 / 19卷 / 10期
关键词：
D O I：
10.1105/tpc.107.052373
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The timing of the developmental transition to flowering is critical to reproductive success in plants. Here, we show that Arabidopsis thaliana homologs of human Lysine-Specific Demethylase1 (LSD1; a histone H3-Lys 4 demethylase) reduce the levels of histone H3-Lys 4 methylation in chromatin of the floral repressor FLOWERING LOCUS C(FLC) and the sporophytically silenced floral repressor FWA. Two of the homologs, LSD1-LIKE1 (LDL1) and LSD1-LIKE2 (LDL2), act in partial redundancy with FLOWERING LOCUS D(FLD; an additional homolog of LSD1) to repress FLC expression. However, LDL1 and LDL2 appear to act independently of FLD in the silencing of FWA, indicating that there is target gene specialization within this histone demethylase family. Loss of function of LDL1 and LDL2 affects DNAmethylation on FWA, whereas FLC repression does not appear to involve DNA methylation; thus, members of the LDL family can participate in a range of silencing mechanisms.
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页码：2975 / 2987
页数：13
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