Antinuclear and anticardiolipin antibodies in primary headache syndrome

Some recent studies report on slightly increased serum levels of anticardiolipin IgG antibodies in patients with migraine with and without aura. Methods:To confirm these results we investigated the frequency of anticardiolipin IgG and IgM antibodies, the anti-nuclear antibodies, and the serum complement in patients with migraine without aura (n=47),migraine with aura (n=10), cluster headache (n=12), and chronic headache of the tension type (n=31) according to the IHS classification and using commercially available tests. Results: Compared with a group of healthy subjects (blood samples were taken during blood donation),the patients with and without migraine had slightly positive anticardiolipin IgG antibodies significantly more often (22.8% to 4.5%). The other headache patients did not exhibit an increased incidence (9.7% and 0%). Compared to the neurological controls (13%)there was a strong tendency towards more often positive titers in the migraine patients. Conclusion: Our finding of increased incidence of positive anticardiolipin IgG antibodies in migraine patients (also reported in other studies) raises the question if these antibodies unspecifically support the occurrence of a migraine attack by increasing the interaction of blood cells and the endothelium. Furthermore,we discuss whether the observed increased inc patients with migraine may in part be caused by the also increased incidence of anticardiolipin antibodies, which are an independent risk factor for stroke.