Delayed surgery after radio-chemotherapy for rectal adenocarcinoma is protective for anastomotic dehiscence: a single-center observational retrospective cohort study

被引：5

作者：

Caputo, Damiano ^{[1
]}

Angeletti, Silvia ^{[2
]}

Fiore, Michele ^{[3
]}

Ciccozzi, Massimo ^{[4
]}

Coppola, Alessandro ^{[5
]}

Cartillone, Mariacristina ^{[1
]}

La Vaccara, Vincenzo ^{[1
]}

Spagnolo, Giuseppe ^{[1
]}

Trodella, Lucio ^{[6
]}

Coppola, Roberto ^{[1
]}

机构：

[1] Univ Campus Biomed Roma, Dept Surg, Via Alvaro del Portillo 200, I-00128 Rome, Italy

[2] Univ Campus Biomed Roma, Unit Clin Lab Sci, Via Alvaro del Portillo 200, I-00128 Rome, Italy

[3] Univ Campus Biomed Roma, Radiat Oncol, Via Alvaro del Portillo 200, I-00128 Rome, Italy

[4] Univ Campus Biomed Roma, Unit Med Stat & Mol Epidemiol, Via Alvaro del Portillo 200, I-00128 Rome, Italy

[5] IRCCS, Fdn Policlin A Gemelli, Gen Surg & Liver Transplant Unit, Rome, Italy

[6] Largo Agostino Gemelli 8, I-00168 Rome, Italy

来源：

UPDATES IN SURGERY | 2020年 / 72卷 / 02期

关键词：

Rectal cancer surgery; Timing; Neoadjuvant; Delayed surgery; TOTAL MESORECTAL EXCISION; NEOADJUVANT CHEMORADIOTHERAPY; CANCER; CHEMORADIATION; RESECTION; INTERVAL; THERAPY; TIME;

D O I：

10.1007/s13304-020-00770-1

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Ideal time interval between end of neoadjuvant radio-chemotherapy (NRCT) and surgery for rectal cancer is debated. Effect that different time intervals have on postoperative complications with particular regard to anastomotic dehiscence (AD) was evaluated on 167 patients who underwent surgery after long-course NRCT. Three different time intervals were considered: (0-42; 43-56; > 57 days). A time interval > 57 days was significantly protective for AD (p = 0.04, Odds ratio = 0.35; 95% CI 0.1254-0.9585) without influence on early oncological outcomes. Optimal time interval after end of NRCT and surgery may help achieving the best pathological response with lowest postoperative morbidity.

引用

页码：469 / 475

页数：7

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