Adaptive immunity in atherosclerosis: mechanisms and future therapeutic targets

被引：182
作者：
Lahoute, Charlotte [1 ]
Herbin, Olivier [1 ]
Mallat, Ziad [1 ]
Tedgui, Alain [1 ]
机构：
[1] Univ Paris 05, Paris Cardiovasc Res Ctr, French Natl Inst Hlth & Med Res, U970, F-75015 Paris, France
来源：
NATURE REVIEWS CARDIOLOGY | 2011年 / 8卷 / 06期
基金：
欧盟第七框架计划;
关键词：
REGULATORY T-CELLS; LOW-DENSITY-LIPOPROTEIN; HEAT-SHOCK-PROTEIN; CORONARY-ARTERY-DISEASE; FACTOR-ALPHA THERAPY; DENDRITIC CELLS; REDUCES ATHEROSCLEROSIS; TGF-BETA; B-CELLS; CAROTID ATHEROSCLEROSIS;
D O I：
10.1038/nrcardio.2011.62
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chronic inflammation drives the development of atherosclerosis, and adaptive immunity is deeply involved in this process. Initial studies attributed a pathogenic role to T cells in atherosclerosis, mainly owing to the proatherogenic role of the T-helper (T-H)-1 cell subset, whereas the influence of T(H)2 and T(H)17 subsets is still debated. Today we know that T regulatory cells play a critical role in the protection against atherosclerotic lesion development and inflammation. In contrast to T cells, B cells were initially considered to be protective in atherosclerosis, assumingly through the production of protective antibodies against oxidized LDL. This concept has now been refined and proatherogenic roles of certain mature B cell subsets have been identified. We review the current knowledge about the role of various lymphocyte subsets in the development and progression of atherosclerosis and highlight future targets for immunomodulatory therapy.
引用
收藏
页码：348 / 358
页数：11
相关论文
共 158 条
[1]   Evidence for the involvement of T cell costimulation through the B-7/CD28 pathway in atherosclerotic plaques from apolipoprotein E knockout mice [J].
Afek, A ;
Harats, D ;
Roth, A ;
Keren, G ;
George, J .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2004, 76 (03) :219-223
[2]   Pathogenesis of Allergic Airway Inflammation [J].
Agrawal, Devendra K. ;
Shao, Zhifei .
CURRENT ALLERGY AND ASTHMA REPORTS, 2010, 10 (01) :39-48
[3]   Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development [J].
Agrawal, Sudesh ;
Febbraio, Maria ;
Podrez, Eugene ;
Cathcart, Martha K. ;
Stark, George R. ;
Chisolm, Guy M. .
CIRCULATION, 2007, 115 (23) :2939-2947
[4]   Natural regulatory T cells control the development of atherosclerosis in mice [J].
Ait-Oufella, H ;
Salomon, BL ;
Potteaux, S ;
Robertson, AKL ;
Gourdy, P ;
Zoll, J ;
Merval, R ;
Esposito, B ;
Cohen, JL ;
Fisson, S ;
Flavell, RA ;
Hansson, GK ;
Klatzmann, D ;
Tedgui, A ;
Mallat, Z .
NATURE MEDICINE, 2006, 12 (02) :178-180
[5]   Measles virus nucleoprotein induces a regulatory immune response and reduces atherosclerosis in mice [J].
Ait-Oufella, Hafid ;
Horvat, Branka ;
Kerdiles, Yann ;
Herbin, Olivier ;
Gourdy, Pierre ;
Khallou-Laschet, Jamila ;
Merval, Regine ;
Esposito, Bruno ;
Tedgui, Alain ;
Mallat, Ziad .
CIRCULATION, 2007, 116 (15) :1707-1713
[6]   B cell depletion reduces the development of atherosclerosis in mice [J].
Ait-Oufella, Hafid ;
Herbin, Olivier ;
Bouaziz, Jean-David ;
Binder, Christoph J. ;
Uyttenhove, Catherine ;
Laurans, Ludivine ;
Taleb, Soraya ;
Van Vre, Emily ;
Esposito, Bruno ;
Vilar, Jose ;
Sirvent, Jerome ;
Van Snick, Jacques ;
Tedgui, Alain ;
Tedder, Thomas F. ;
Mallat, Ziad .
JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (08) :1579-1587
[7]   Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells [J].
Allan, Lenka L. ;
Hoefl, Katrin ;
Zheng, Dong-Jun ;
Chung, Brian K. ;
Kozak, Frederick K. ;
Tan, Rusung ;
van den Elzen, Peter .
BLOOD, 2009, 114 (12) :2411-2416
[8]   Circulating CD4+ CD25hiCD127lo Regulatory T-Cell Levels Do Not Reflect the Extent or Severity of Carotid and Coronary Atherosclerosis [J].
Ammirati, Enrico ;
Cianflone, Domenico ;
Banfi, Michela ;
Vecchio, Viviana ;
Palini, Alessio ;
De Metrio, Monica ;
Marenzi, Giancarlo ;
Panciroli, Claudio ;
Tumminello, Gabriele ;
Anzuini, Angelo ;
Palloshi, Altin ;
Grigore, Liliana ;
Garlaschelli, Katia ;
Tramontana, Simona ;
Tavano, Davide ;
Airoldi, Flavio ;
Manfredi, Angelo A. ;
Catapano, Alberico Luigi ;
Norata, Giuseppe Danilo .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2010, 30 (09) :1832-U359
[9]   In vivo instruction of suppressor commitment in naive T cells [J].
Apostolou, I ;
von Boehmer, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (10) :1401-1408
[10]   B-lymphocytes in plaque and adventitia of coronary arteries in two patients with rheumatoid arthritis and coronary atherosclerosis - Preliminary observations [J].
Aubry, MC ;
Riehle, DL ;
Edwards, WD ;
Maradit-Kremers, H ;
Roger, VL ;
Sebo, TJ ;
Gabriel, SE .
CARDIOVASCULAR PATHOLOGY, 2004, 13 (04) :233-236
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