Evaluation of antiplasmodial activity of Berlina grandiflora leaf extract against Plasmodium berghei in mice

被引：0

作者：

Akuodor, G. C. ^{[1
]}

Anyalewechi, N. A. ^{[1
]}

Ikoro, N. C. ^{[2
]}

Akpan, J. L. ^{[3
]}

Megwas, U. A. ^{[4
]}

Iwuanyanwu, T. C. ^{[1
]}

Osunkwo, U. A. ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Res & Dev NIPRD Idu, Dept Pharmacol & Toxicol, Garki, Abuja, Nigeria

[2] Fed Univ Technol Owerri, Dept Optometry & Opt Technol, Owerri, Nigeria

[3] Ebonyi State Univ, Fac Clin Med, Dept Pharmacol & Therapeut, Abakaliki, Nigeria

[4] Imo State Univ, Dept Optometry, Owerri, Nigeria

来源：

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH | 2010年 / 4卷 / 21期

关键词：

Berlina grandiflora; medicinal plant; antimalarial activity; Plasmodium berghei;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vivo antiplasmodial activity of methanol leaf extract of Berlina grandiflora was investigated in Plasmodium berghei infected mice. Four day suppressive and curative effect against established infection models of antiplasmodial studies was used. The extract (100 to 400 mg/kg, p.o.) exhibited significant (p < 0.05) antiplasmodial activity in early and established infection tests with a considerable mean survival time comparable to that of chloroquine, 10 mg/kg. The leaf extract showed a significant (p < 0.05) activity against the parasite in the suppressive and curative tests. The finding supports the traditional use of the plant for the treatment of malaria.

引用

页码：2211 / 2214

页数：4

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