Integrative epigenetic taxonomy of primary prostate cancer

被引：107

作者：

Stelloo, Suzan ^{[1
]}

Nevedomskaya, Ekaterina ^{[1
,2
]}

Kim, Yongsoo ^{[1
,2
]}

Schuurman, Karianne ^{[1
]}

Valle-Encinas, Eider ^{[1
]}

Lobo, Joao ^{[3
,4
,5
]}

Krijgsman, Oscar ^{[6
]}

Peeper, Daniel Simon ^{[6
]}

Chang, Seiwon Laura ^{[7
]}

Feng, Felix Yi-Chung ^{[7
]}

Wessels, Lodewyk Frederik Ary ^{[2
,8
]}

Henrique, Rui ^{[3
,4
,5
]}

Jeronimo, Carmen ^{[3
,4
,5
]}

Bergman, Andries Marinus ^{[9
,10
]}

Zwart, Wilbert ^{[1
,11
,12
]}

机构：

[1] Netherlands Canc Inst, Oncode Inst, Div Oncogenom, NL-1066 CX Amsterdam, Netherlands

[2] Netherlands Canc Inst, Oncode Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

[3] Portuguese Oncol Inst Porto, Canc Biol & Epigenet Grp, Res Ctr, P-4200072 Porto, Portugal

[4] Portuguese Oncol Inst Porto, Dept Pathol, P-4200072 Porto, Portugal

[5] Univ Porto, Inst Biomed Sci Abel Salazar ICBAS, Dept Pathol & Mol Immunol, P-4050313 Porto, Portugal

[6] Netherlands Canc Inst, Oncode Inst, Div Mol Oncol & Immunol, NL-1066 CX Amsterdam, Netherlands

[7] UCSF, Dept Radiat Oncol, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94115 USA

[8] Delft Univ Technol, Fac EEMCS, NL-2628 CD Delft, Netherlands

[9] Netherlands Canc Inst, Div Med Oncol, NL-1066 CX Amsterdam, Netherlands

[10] Netherlands Canc Inst, Div Oncogenom, NL-1066 CX Amsterdam, Netherlands

[11] Eindhoven Univ Technol, Dept Biomed Engn, Lab Chem Biol, POB 513, NL-5600 MB Eindhoven, Netherlands

[12] Eindhoven Univ Technol, Dept Biomed Engn, Inst Complex Mol Syst, POB 513, NL-5600 MB Eindhoven, Netherlands

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

ANDROGEN RECEPTOR; SEQUENCING DATA; BREAST-CANCER; MUTATIONS; REVEALS; TUMORIGENESIS; PROGRESSION; RESISTANCE; DISCOVERY; PATHWAYS;

D O I：

10.1038/s41467-018-07270-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Androgen Receptor (AR) is the key-driving transcription factor in prostate cancer, tightly controlled by epigenetic regulation. To date, most epigenetic profiling has been performed in cell lines or limited tissue samples. Here, to comprehensively study the epigenetic landscape, we perform RNA-seq with ChIP-seq for AR and histone modification marks (H3K27ac, H3K4me3, H3K27me3) in 100 primary prostate carcinomas. Integrative molecular subtyping of the five data streams revealed three major subtypes of which two were clearly TMPRSS2ERG dictated. Importantly, we identify a third subtype with low chromatin binding and activity of AR, but with high activity of FGF and WNT signaling. While positive for neuroendocrine-hallmark genes, these tumors were copy number-neutral with low mutational burden, significantly depleted for genes characteristic of poor-outcome associated luminal B-subtype. We present a unique resource on transcriptional and epigenetic control in prostate cancer, revealing tight control of gene regulation differentially dictated by AR over three subtypes.

引用

页数：12

共 52 条

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Abeshouse, Adam ;

Ahn, Jaeil ;

Akbani, Rehan ;

Ally, Adrian ;

Amin, Samirkumar ;

Andry, Christopher D. ;

Annala, Matti ;

Aprikian, Armen ;

Armenia, Joshua ;

Arora, Arshi ;

Auman, J. Todd ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barbieri, Christopher E. ;

Bauer, Thomas ;

Benz, Christopher C. ;

Bergeron, Alain ;

Beroukhim, Rameen ;

Berrios, Mario ;

Bivol, Adrian ;

Bodenheimer, Tom ;

Boice, Lori ;

Bootwalla, Moiz S. ;

dos Reis, Rodolfo Borges ;

Boutros, Paul C. ;

Bowen, Jay ;

Bowlby, Reanne ;

Boyd, Jeffrey ;

Bradley, Robert K. ;

Breggia, Anne ;

Brimo, Fadi ;

Bristow, Christopher A. ;

Brooks, Denise ;

Broom, Bradley M. ;

Bryce, Alan H. ;

Bubley, Glenn ;

Burks, Eric ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Canes, David ;

Carlotti, Carlos G. ;

Carlsen, Rebecca ;

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Chang, Matthew T. ;

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Armenia, Joshua ;

Wankowicz, Stephanie A. M. ;

Liu, David ;

Gao, Jianjiong ;

Kundra, Ritika ;

Reznik, Ed ;

Chatila, Walid K. ;

Chakravarty, Debyani ;

Han, G. Celine ;

Coleman, Ilsa ;

Montgomery, Bruce ;

Pritchard, Colin ;

Morrissey, Colm ;

Barbieri, Christopher E. ;

Beltran, Himisha ;

Sboner, Andrea ;

Zafeiriou, Zafeiris ;

Miranda, Susana ;

Bielski, Craig M. ;

Penson, Alexander V. ;

Tolonen, Charlotte ;

Huang, Franklin W. ;

Robinson, Dan ;

Wu, Yi Mi ;

Lonigro, Robert ;

Garraway, Levi A. ;

Demichelis, Francesca ;

Kantoff, Philip W. ;

Taplin, Mary-Ellen ;

Abida, Wassim ;

Taylor, Barry S. ;

Scher, Howard I. ;

Nelson, Peter S. ;

de Bono, Johann S. ;

Rubin, Mark A. ;

Sawyers, Charles L. ;

Chinnaiyan, Arul M. ;

Schultz, Nikolaus ;

Van Allen, Eliezer M. .

NATURE GENETICS, 2018, 50 (05) :645-+

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Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[4] Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer [J].

Beltran, Himisha ;

Prandi, Davide ;

Mosquera, Juan Miguel ;

Benelli, Matteo ;

Puca, Loredana ;

Cyrta, Joanna ;

Marotz, Clarisse ;

Giannopoulou, Eugenia ;

Chakravarthi, Balabhadrapatruni V. S. K. ;

Varambally, Sooryanarayana ;

Tomlins, Scott A. ;

Nanus, David M. ;

Tagawa, Scott T. ;

Van Allen, Eliezer M. ;

Elemento, Olivier ;

Sboner, Andrea ;

Garraway, Levi A. ;

Rubin, Mark A. ;

Demichelis, Francesca .

NATURE MEDICINE, 2016, 22 (03) :298-305

[5] Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets [J].

Beltran, Himisha ;

Rickman, David S. ;

Park, Kyung ;

Chae, Sung Suk ;

Sboner, Andrea ;

MacDonald, Theresa Y. ;

Wang, Yuwei ;

Sheikh, Karen L. ;

Terry, Stephane ;

Tagawa, Scott T. ;

Dhir, Rajiv ;

Nelson, Joel B. ;

de la Taille, Alexandre ;

Allory, Yves ;

Gerstein, Mark B. ;

Perner, Sven ;

Pienta, Kenneth J. ;

Chinnaiyan, Arul M. ;

Wang, Yuzhuo ;

Collins, Colin C. ;

Gleave, Martin E. ;

Demichelis, Francesca ;

Nanus, David M. ;

Rubin, Mark A. .

CANCER DISCOVERY, 2011, 1 (06) :487-495

[6] SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts [J].

Blattner, Mirjam ;

Lee, Daniel J. ;

O'Reilly, Catherine ;

Park, Kyung ;

MacDonald, Theresa Y. ;

Khani, Francesca ;

Turner, Kevin R. ;

Chiu, Ya-Lin ;

Wild, Peter J. ;

Dolgalev, Igor ;

Heguy, Adriana ;

Sboner, Andrea ;

Ramazangolu, Sinan ;

Hieronymus, Haley ;

Sawyers, Charles ;

Tewari, Ashutosh K. ;

Moch, Holger ;

Yoon, Ghil Suk ;

Known, Yong Chul ;

Andren, Ove ;

Fall, Katja ;

Demichelis, Francecsa ;

Mosquera, Juan Miguel ;

Robinson, Brian D. ;

Barbieri, Christopher E. ;

Rubin, Mark A. .

NEOPLASIA, 2014, 16 (01) :14-U34

[7] Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling [J].

Bluemn, Eric G. ;

Coleman, Ilsa M. ;

Lucas, Jared M. ;

Coleman, Roger T. ;

Hernandez-Lopez, Susana ;

Tharakan, Robin ;

Bianchi-Frias, Daniella ;

Dumpit, Ruth F. ;

Kaipainen, Arja ;

Corella, Alexandra N. ;

Yang, Yu Chi ;

Nyquist, Michael D. ;

Mostaghel, Elahe ;

Hsieh, Andrew C. ;

Zhang, Xiaotun ;

Corey, Eva ;

Brown, Lisha G. ;

Nguyen, Holly M. ;

Pienta, Kenneth ;

Ittmann, Michael ;

Schweizer, Michael ;

True, Lawrence D. ;

Wise, David ;

Rennie, Paul S. ;

Vessella, Robert L. ;

Morrissey, Colm ;

Nelson, Peter S. .

CANCER CELL, 2017, 32 (04) :474-+

[8] Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data [J].

Camacho, Niedzica ;

Van Loo, Peter ;

Edwards, Sandra ;

Kay, Jonathan D. ;

Matthews, Lucy ;

Haase, Kerstin ;

Clark, Jeremy ;

Dennis, Nening ;

Thomas, Sarah ;

Kremeyer, Barbara ;

Zamora, Jorge ;

Butler, Adam P. ;

Gundem, Gunes ;

Merson, Sue ;

Luxton, Hayley ;

Hawkins, Steve ;

Ghori, Mohammed ;

Marsden, Luke ;

Lambert, Adam ;

Karaszi, Katalin ;

Pelvender, Gill ;

Massie, Charlie E. ;

Kote-Jarai, ZSofia ;

Raine, Keiran ;

Jones, David ;

Howat, William J. ;

Hazell, Steven ;

Livni, Naomi ;

Fisher, Cyril ;

Ogden, Christopher ;

Kumar, Pardee ;

Thompson, Alan ;

Nicol, David ;

Mayer, Erik ;

Dudderidge, Tim ;

Yu, Yongwei ;

Zhang, Hongwei ;

Shah, Nimish C. ;

Gnanapragasam, Vincent J. ;

Isaacs, William ;

Visakorpi, Tapio ;

Hamdy, Freddie ;

Berney, Dan ;

Verri, Clare ;

Warren, Anne Y. ;

Wedge, David C. ;

Lynch, Andrew G. ;

Foster, Christopher S. ;

Lu, Yong Jie ;

Bova, G. Steven .

PLOS GENETICS, 2017, 13 (09)

[9] Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer [J].

Chen, Zhong ;

Lan, Xun ;

Thomas-Ahner, Jennifer M. ;

Wu, Dayong ;

Liu, Xiangtao ;

Ye, Zhenqing ;

Wang, Liguo ;

Sunkel, Benjamin ;

Grenade, Cassandra ;

Chen, Junsheng ;

Zynger, Debra L. ;

Yan, Pearlly S. ;

Huang, Jiaoti ;

Nephew, Kenneth P. ;

Huang, Tim H-M ;

Lin, Shili ;

Clinton, Steven K. ;

Li, Wei ;

Jin, Victor X. ;

Wang, Qianben .

EMBO JOURNAL, 2015, 34 (04) :502-516

[10] TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data [J].

Colaprico, Antonio ;

Silva, Tiago C. ;

Olsen, Catharina ;

Garofano, Luciano ;

Cava, Claudia ;

Garolini, Davide ;

Sabedot, Thais S. ;

Malta, Tathiane M. ;

Pagnotta, Stefano M. ;

Castiglioni, Isabella ;

Ceccarelli, Michele ;

Bontempi, Gianluca ;

Noushmehr, Houtan .

NUCLEIC ACIDS RESEARCH, 2016, 44 (08) :e71

← 1 2 3 4 5 6 →

共 52 条

[1] The Molecular Taxonomy of Primary Prostate Cancer [J].

Abeshouse, Adam ;

Ahn, Jaeil ;

Akbani, Rehan ;

Ally, Adrian ;

Amin, Samirkumar ;

Andry, Christopher D. ;

Annala, Matti ;

Aprikian, Armen ;

Armenia, Joshua ;

Arora, Arshi ;

Auman, J. Todd ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barbieri, Christopher E. ;

Bauer, Thomas ;

Benz, Christopher C. ;

Bergeron, Alain ;

Beroukhim, Rameen ;

Berrios, Mario ;

Bivol, Adrian ;

Bodenheimer, Tom ;

Boice, Lori ;

Bootwalla, Moiz S. ;

dos Reis, Rodolfo Borges ;

Boutros, Paul C. ;

Bowen, Jay ;

Bowlby, Reanne ;

Boyd, Jeffrey ;

Bradley, Robert K. ;

Breggia, Anne ;

Brimo, Fadi ;

Bristow, Christopher A. ;

Brooks, Denise ;

Broom, Bradley M. ;

Bryce, Alan H. ;

Bubley, Glenn ;

Burks, Eric ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Canes, David ;

Carlotti, Carlos G. ;

Carlsen, Rebecca ;

Carmel, Michel ;

Carroll, Peter R. ;

Carter, Scott L. ;

Cartun, Richard ;

Carver, Brett S. ;

Chan, June M. ;

Chang, Matthew T. ;

Chen, Yu .

CELL, 2015, 163 (04) :1011-1025

[2] The long tail of oncogenic drivers in prostate cancer [J].

Armenia, Joshua ;

Wankowicz, Stephanie A. M. ;

Liu, David ;

Gao, Jianjiong ;

Kundra, Ritika ;

Reznik, Ed ;

Chatila, Walid K. ;

Chakravarty, Debyani ;

Han, G. Celine ;

Coleman, Ilsa ;

Montgomery, Bruce ;

Pritchard, Colin ;

Morrissey, Colm ;

Barbieri, Christopher E. ;

Beltran, Himisha ;

Sboner, Andrea ;

Zafeiriou, Zafeiris ;

Miranda, Susana ;

Bielski, Craig M. ;

Penson, Alexander V. ;

Tolonen, Charlotte ;

Huang, Franklin W. ;

Robinson, Dan ;

Wu, Yi Mi ;

Lonigro, Robert ;

Garraway, Levi A. ;

Demichelis, Francesca ;

Kantoff, Philip W. ;

Taplin, Mary-Ellen ;

Abida, Wassim ;

Taylor, Barry S. ;

Scher, Howard I. ;

Nelson, Peter S. ;

de Bono, Johann S. ;

Rubin, Mark A. ;

Sawyers, Charles L. ;

Chinnaiyan, Arul M. ;

Schultz, Nikolaus ;

Van Allen, Eliezer M. .

NATURE GENETICS, 2018, 50 (05) :645-+

[3] Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer [J].

Barbieri, Christopher E. ;

Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[4] Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer [J].

Beltran, Himisha ;

Prandi, Davide ;

Mosquera, Juan Miguel ;

Benelli, Matteo ;

Puca, Loredana ;

Cyrta, Joanna ;

Marotz, Clarisse ;

Giannopoulou, Eugenia ;

Chakravarthi, Balabhadrapatruni V. S. K. ;

Varambally, Sooryanarayana ;

Tomlins, Scott A. ;

Nanus, David M. ;

Tagawa, Scott T. ;

Van Allen, Eliezer M. ;

Elemento, Olivier ;

Sboner, Andrea ;

Garraway, Levi A. ;

Rubin, Mark A. ;

Demichelis, Francesca .

NATURE MEDICINE, 2016, 22 (03) :298-305

[5] Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets [J].

Beltran, Himisha ;

Rickman, David S. ;

Park, Kyung ;

Chae, Sung Suk ;

Sboner, Andrea ;

MacDonald, Theresa Y. ;

Wang, Yuwei ;

Sheikh, Karen L. ;

Terry, Stephane ;

Tagawa, Scott T. ;

Dhir, Rajiv ;

Nelson, Joel B. ;

de la Taille, Alexandre ;

Allory, Yves ;

Gerstein, Mark B. ;

Perner, Sven ;

Pienta, Kenneth J. ;

Chinnaiyan, Arul M. ;

Wang, Yuzhuo ;

Collins, Colin C. ;

Gleave, Martin E. ;

Demichelis, Francesca ;

Nanus, David M. ;

Rubin, Mark A. .

CANCER DISCOVERY, 2011, 1 (06) :487-495

[6] SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts [J].

Blattner, Mirjam ;

Lee, Daniel J. ;

O'Reilly, Catherine ;

Park, Kyung ;

MacDonald, Theresa Y. ;

Khani, Francesca ;

Turner, Kevin R. ;

Chiu, Ya-Lin ;

Wild, Peter J. ;

Dolgalev, Igor ;

Heguy, Adriana ;

Sboner, Andrea ;

Ramazangolu, Sinan ;

Hieronymus, Haley ;

Sawyers, Charles ;

Tewari, Ashutosh K. ;

Moch, Holger ;

Yoon, Ghil Suk ;

Known, Yong Chul ;

Andren, Ove ;

Fall, Katja ;

Demichelis, Francecsa ;

Mosquera, Juan Miguel ;

Robinson, Brian D. ;

Barbieri, Christopher E. ;

Rubin, Mark A. .

NEOPLASIA, 2014, 16 (01) :14-U34

[7] Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling [J].

Bluemn, Eric G. ;

Coleman, Ilsa M. ;

Lucas, Jared M. ;

Coleman, Roger T. ;

Hernandez-Lopez, Susana ;

Tharakan, Robin ;

Bianchi-Frias, Daniella ;

Dumpit, Ruth F. ;

Kaipainen, Arja ;

Corella, Alexandra N. ;

Yang, Yu Chi ;

Nyquist, Michael D. ;

Mostaghel, Elahe ;

Hsieh, Andrew C. ;

Zhang, Xiaotun ;

Corey, Eva ;

Brown, Lisha G. ;

Nguyen, Holly M. ;

Pienta, Kenneth ;

Ittmann, Michael ;

Schweizer, Michael ;

True, Lawrence D. ;

Wise, David ;

Rennie, Paul S. ;

Vessella, Robert L. ;

Morrissey, Colm ;

Nelson, Peter S. .

CANCER CELL, 2017, 32 (04) :474-+

[8] Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data [J].

Camacho, Niedzica ;

Van Loo, Peter ;

Edwards, Sandra ;

Kay, Jonathan D. ;

Matthews, Lucy ;

Haase, Kerstin ;

Clark, Jeremy ;

Dennis, Nening ;

Thomas, Sarah ;

Kremeyer, Barbara ;

Zamora, Jorge ;

Butler, Adam P. ;

Gundem, Gunes ;

Merson, Sue ;

Luxton, Hayley ;

Hawkins, Steve ;

Ghori, Mohammed ;

Marsden, Luke ;

Lambert, Adam ;

Karaszi, Katalin ;

Pelvender, Gill ;

Massie, Charlie E. ;

Kote-Jarai, ZSofia ;

Raine, Keiran ;

Jones, David ;

Howat, William J. ;

Hazell, Steven ;

Livni, Naomi ;

Fisher, Cyril ;

Ogden, Christopher ;

Kumar, Pardee ;

Thompson, Alan ;

Nicol, David ;

Mayer, Erik ;

Dudderidge, Tim ;

Yu, Yongwei ;

Zhang, Hongwei ;

Shah, Nimish C. ;

Gnanapragasam, Vincent J. ;

Isaacs, William ;

Visakorpi, Tapio ;

Hamdy, Freddie ;

Berney, Dan ;

Verri, Clare ;

Warren, Anne Y. ;

Wedge, David C. ;

Lynch, Andrew G. ;

Foster, Christopher S. ;

Lu, Yong Jie ;

Bova, G. Steven .

PLOS GENETICS, 2017, 13 (09)

[9] Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer [J].

Chen, Zhong ;

Lan, Xun ;

Thomas-Ahner, Jennifer M. ;

Wu, Dayong ;

Liu, Xiangtao ;

Ye, Zhenqing ;

Wang, Liguo ;

Sunkel, Benjamin ;

Grenade, Cassandra ;

Chen, Junsheng ;

Zynger, Debra L. ;

Yan, Pearlly S. ;

Huang, Jiaoti ;

Nephew, Kenneth P. ;

Huang, Tim H-M ;

Lin, Shili ;

Clinton, Steven K. ;

Li, Wei ;

Jin, Victor X. ;

Wang, Qianben .

EMBO JOURNAL, 2015, 34 (04) :502-516

[10] TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data [J].

Colaprico, Antonio ;

Silva, Tiago C. ;

Olsen, Catharina ;

Garofano, Luciano ;

Cava, Claudia ;

Garolini, Davide ;

Sabedot, Thais S. ;

Malta, Tathiane M. ;

Pagnotta, Stefano M. ;

Castiglioni, Isabella ;

Ceccarelli, Michele ;

Bontempi, Gianluca ;

Noushmehr, Houtan .

NUCLEIC ACIDS RESEARCH, 2016, 44 (08) :e71

← 1 2 3 4 5 6 →