Successful Isavuconazole Salvage Therapy for a Cryptococcus deuterogattii (AFLP6/VGII) Disseminated Infection in a European Immunocompetent Patient

被引：7

作者：

Cuetara, Maria Soledad ^{[1
]}

Jusdado Ruiz-Capillas, Juan Jose ^{[2
]}

Nunez-Valentin, Maria Pilar ^{[3
]}

Rodriguez Garcia, Elena ^{[4
]}

Garcia-Benayas, Elena ^{[5
]}

Rojo-Amigo, Ricardo ^{[6
]}

Rodriguez-Gallego, Jose Carlos ^{[7
]}

Hagen, Ferry ^{[8
,9
,10
]}

Colom, Maria Francisca ^{[11
,12
]}

机构：

[1] Hosp Univ Severo Ochoa, Dept Microbiol, Avda Orellana S-N, Madrid 28914, Spain

[2] Hosp Univ Severo Ochoa, Dept Med, Madrid, Spain

[3] Hosp Univ Severo Ochoa, Dept Radiol, Madrid, Spain

[4] Hosp Univ Severo Ochoa, Dept Neurol, Madrid, Spain

[5] Hosp Univ Severo Ochoa, Dept Pharm, Madrid, Spain

[6] Hosp Maternoinfantil CHUAC, Dept Immunol, La Coruna, Spain

[7] Hosp Dr Negrin, Dept Immunol, Palmas De Gran Canaria, Spain

[8] Westerdijk Fungal Biodivers Inst, Utrecht, Netherlands

[9] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands

[10] Jining 1 Peoples Hosp, Med Mycol Lab, Jining, Shandong, Peoples R China

[11] Univ Miguel Hernandez, Dept Plant Prod & Microbiol, Med Mycol Lab, Campus St Joan DAlacant, Alicante 03550, Spain

[12] Inst Healthcare & Biomed Res Alicante, Isabial, Spain

来源：

MYCOPATHOLOGIA | 2021年 / 186卷 / 04期

关键词：

Cryptococcus deuterogattii; Isavuconazole; Multi-locus sequence typing; Amplified fragment length polymorphism; Environmental sampling; GATTII INFECTION; BRITISH-COLUMBIA; NEOFORMANS; MANAGEMENT; EPIDEMIOLOGY; DIAGNOSIS; CANADA;

D O I：

10.1007/s11046-021-00566-w

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Members of the Cryptococcus gattii species complex are notorious causes of cryptococcosis as they often cause severe, life-threatening infections. Here we describe a case of a severe disseminated C. deuterogattii infection in a previously healthy patient who was initially treated with amphotericin B, 5-fluorocytosine and fluconazole, which led to a good neurological response, but the infection in the lungs remained unaltered and was not completely resolved until switching the antifungal therapy to isavuconazole. The infection was likely acquired during a one-month stay at the Azores Islands, Portugal. Environmental sampling did not yield any cryptococcal isolate; therefore, the source of this apparent autochthonous case could not be determined. Molecular typing showed that the cultured C. deuterogattii isolates were closely related to the Vancouver Island outbreak-genotype.

引用

页码：507 / 518

页数：12

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