THE ALBUMIN-GLOBULIN RATIO PREDICTING MORTALITY IN GASTRIC CARCINOMA

被引：3

作者：

Aksoy, Asude ^{[1
]}

Durak, Serdar ^{[2
]}

Ozturk, Turkan ^{[3
]}

Avci, Nilufer ^{[4
]}

Cirak, Yalcin ^{[5
]}

Deger, Ayse Nur ^{[6
]}

Bilgic, Yilmaz ^{[7
]}

Koca, Suleyman Serdar ^{[2
]}

Ozcan, Mete ^{[8
]}

Goktas, Sevil ^{[9
]}

Bozdag, Ahmet ^{[10
]}

机构：

[1] Firat Univ, Fac Med, Med Oncol, Elazig, Turkey

[2] Firat Univ, Med Fac Internal Med, Elazig, Turkey

[3] Karadeniz Tech Univ, Fac Med, Med Oncol, Trabzon, Turkey

[4] Bursa Ali Osman Sonmez Oncol Hosp, Med Oncol, Bursa, Turkey

[5] Istanbul Bahcesehir Univ, Fac Med, Med Oncol, Istanbul, Turkey

[6] Dumlupinar Univ, Fac Med, Pathol, Kutahya, Turkey

[7] Inonu Univ, Fac Med, Gastroenterol, Malatya, Turkey

[8] Firat Univ, Fac Med, Biophys, Malatya, Turkey

[9] Denizli State Hosp, Med Oncol, Denizli, Turkey

[10] Elazig Educ & Res Hosp, Gen Surg, Elazig, Turkey

来源：

ACTA MEDICA MEDITERRANEA | 2016年 / 32卷 / 03期

关键词：

Albumin-globulin ratio; albumin; gastric carcinoma; predictive; survival; GLASGOW PROGNOSTIC SCORE; LONG-TERM MORTALITY; CARCINOEMBRYONIC ANTIGEN; HEPATOCELLULAR-CARCINOMA; CURATIVE RESECTION; NUTRITIONAL-STATUS; CA; 72-4; SURVIVAL; CANCER; INFLAMMATION;

D O I：

10.19193/0393-6384_2016_3_78

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: The potential effects of serum albumin and albumin-globulin rate on survival were investigated in patients with gastric carcinoma. Materials and methods: The biochemical values of 204 patients under chemotherapy evaluation were obtained retrospectively from archive data. Albumin-globulin ratio values were calculated using albumin/total protein-albumin formula. The values of albumin-globulin ratio and albumin were categorized as 3 groups using receiver operating characteristic analysis and a descending order. Results: The calculated cut-off value for albumin-globulin ratio was 1.14: 34.4-79.7 by receiver operating characteristic. The median survival was 20.7 months (15.9-25.5), 20.1 months (15.1-25.1), 16 months (11.8-20.1), respectively in 1st, 2nd, 3rd groups for albumin-globulin ratio (p=0.46). The median overall survival was 18.3 months (123-24.2), 21.6 months (16.8-26.3), 18.01 months (13.5-22.4) in 1st, 2nd, 3rd groups for albumin, respectively (p=0.52). There were no statistical significant differences by Kaplan-Meier method for albumin-globulin ratio, albumin p>0.05. The effects of clinicopathological and biochemical characteristics on mortality were assessed by Cox-proportional hazard regression analysis. The independent predictors of mortality were observed high grade, the presence of perineural invasion of the tumor, high nodal involvement (p:0.01, p:0.001, p:0.01), respectively. Conclusion: Albumin-globulin ratio and albumin values alone may not be useful parameters to predict mortality and survival in patients with gastric carcinoma.

引用

页码：707 / 712

页数：6

共 31 条

[11] Albumin-globulin Ratio for Prediction of Long-term Mortality in Lung Adenocarcinoma Patients [J].