Family-based association studies of monoaminergic gene polymorphisms among North Indians with schizophrenia

被引：41

作者：

Semwal, P

Prasad, S

Bhatia, T

Deshpande, SN

Wood, J

Nimgaonkar, VL

Thelma, BK

机构：

[1] Univ Delhi, Dept Genet, New Delhi, India

[2] Indo US Project Schizophrenia Genet, New Delhi, India

[3] Dr RML Hosp, Dept Psychiat, New Delhi, India

[4] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[5] Univ Pittsburgh, Sch Med, Dept Human Genet, Pittsburgh, PA USA

[6] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA USA

[7] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Psychiat, Pittsburgh, PA USA

来源：

MOLECULAR PSYCHIATRY | 2001年 / 6卷 / 02期

关键词：

schizophrenia; genetics; serotonin 2A receptor; tryptophan hydroxylase; dopamine transporter; catechol-O-methyltransferase;

D O I：

10.1038/sj.mp.4000839

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Associations between schizophrenia and four candidate genes were tested among Indian patients with schizophrenia and their parents (DSM-IV criteria, n = 179 families). Polymorphisms within the genes encoding the serotonin 2A receptor (HT2A), tryptophan hydroxylase (TPH), catechol-O-methyl transferase (COMT) and dopamine transporter (DAT) were thus investigated. Two polymorphisms each were analyzed at HT2A and TPH, enabling haplotype-based analyses using the transmission disequilibrium test (TDT) for these genes. No significant associations were detected. Pooled analysis of samples like ours may be necessary to definitively exclude putative allelic associations at these loci.

引用

页码：220 / 224

页数：5

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