The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred

被引：30

作者：

Mai, Phuong L. ^{[1
]}

Friedlander, Michael ^{[2
,3
]}

Tucker, Kathy ^{[2
,3
]}

Phillips, Kelly-Anne ^{[4
]}

Hogg, David ^{[5
,6
]}

Jewett, Michael A. S. ^{[5
,6
]}

Lohynska, Radka ^{[7
]}

Daugaard, Gedske ^{[8
]}

Richard, Stephane ^{[9
,10
,11
]}

Bonaiti-Pellie, Catherine ^{[12
,13
]}

Heidenreich, Axel ^{[14
]}

Albers, Peter ^{[15
]}

Bodrogi, Istvan ^{[16
]}

Geczi, Lajos ^{[16
,17
]}

Olah, Edith ^{[16
,17
]}

Daly, Peter A. ^{[18
]}

Guilford, Parry ^{[19
]}

Fossa, Sophie D. ^{[20
,24
]}

Heimdal, Ketil ^{[20
,24
]}

Liubchenko, Ludmila ^{[21
]}

Tjulandin, Sergei A. ^{[21
]}

Stoll, Hans ^{[22
]}

Weber, Walter ^{[22
]}

Easton, Douglas F. ^{[23
]}

Dudakia, Darshna ^{[25
]}

Huddart, Robert ^{[26
]}

Stratton, Michael R. ^{[25
]}

Einhorn, Lawrence ^{[27
]}

Korde, Larissa ^{[1
]}

Nathanson, Katherine L. ^{[28
]}

Bishop, Timothy ^{[29
]}

Rapley, Elizabeth A. ^{[25
]}

Greene, Mark H. ^{[1
]}

机构：

[1] NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD 20852 USA

[2] Univ New S Wales, Dept Med Oncol, Div Med, Sydney, NSW, Australia

[3] Prince Wales Hosp Randwick, Sydney, NSW, Australia

[4] Peter MacCallum Canc Ctr, Dept Haematol & Med Oncol, Melbourne, Australia

[5] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada

[6] Univ Toronto, Toronto, ON, Canada

[7] Univ Hosp, Dept Radiotherapy & Oncol, Prague, Czech Republic

[8] Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark

[9] Fac Med Paris Sud, Genet Oncol EPHE CNRS FRE 2939, Paris, France

[10] CHU, Serv Urol, Le Kremlin Bicetre, France

[11] Inst Gustave Roussy, Villejuif, France

[12] INSERM, U535, F-94817 Villejuif, France

[13] Univ Paris Sud, Villejuif, France

[14] Univ Cologne, Dept Urol, Div Oncol Urol, Cologne, Germany

[15] Klinikum Kassel GmbH, Dept Urol, Kassel, Germany

[16] Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary

[17] Natl Inst Oncol, Dept Chemotherapy, Budapest, Hungary

[18] St James Hosp, Dept Med Oncol, Dublin, Ireland

[19] Univ Otago, Canc Genet Lab, Dunedin, New Zealand

[20] Radiumhosp, Rikshosp, Dept Clin Canc Res, Oslo, Norway

[21] NN Blokhin Russian Canc Res Ctr, Lab Clin Genet, Inst Clin Oncol, Moscow, Russia

[22] Univ Basel Hosp, CH-4031 Basel, Switzerland

[23] CRC Genet Epidemiol Unit, Cambridge, England

[24] Radiumhosp, Rikshosp, Dept Med Genet, Oslo, Norway

[25] Inst Canc Res, Sect Canc Genet, Sutton, Surrey, England

[26] Inst Canc Res, Acad Radiotherapy Unit, Sutton, Surrey, England

[27] Indiana Univ, Dept Med, Sch Med, Indianapolis, IN 46204 USA

[28] Univ Penn, Sch Med, Div Med Genet, Dept Med, Philadelphia, PA 19104 USA

[29] Imperial Canc Res Fund Genet Epidemiol Lab, Leeds, W Yorkshire, England

来源：

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2010年 / 28卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Testicular neoplasms; Familial; Epidemiology; Clinicopathologic characteristics; OF-THE-LITERATURE; SUSCEPTIBILITY GENES; RISK-FACTORS; EXPERIENCE; ANTICIPATION; EPIDEMIOLOGY; POPULATION; TESTIS; FATHER;

D O I：

10.1016/j.urolonc.2008.10.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. Materials and methods: Families with >= 2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families. Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism. TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families. Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial eases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation. Published by Elsevier Inc.

引用

页码：492 / 499

页数：8

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