Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells

被引：64

作者：

Liu, Jie ^{[1
,2
]}

Shimizu, Kuniyoshi ^{[1
]}

Yu, Hongshan ^{[3
]}

Zhang, Chunzhi ^{[3
]}

Jin, Fengxie ^{[3
]}

Kondo, Ryuichiro ^{[1
]}

机构：

[1] Kyushu Univ, Fac Agr, Dept Forest & Forest Prod Sci, Fukuoka 8128581, Japan

[2] N Carolina State Univ, Coll Nat Resources, Dept Forestry & Environm Resources, Raleigh, NC 27695 USA

[3] Dalian Polytech Univ, Coll Bio & Food Technol, Dalian 116034, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 07期

关键词：

Ginseng; Ginsenoside; Prostate cancer cell; IN-VIVO; PROLIFERATION; EXPRESSION; SAPONINS; LINE;

D O I：

10.1016/j.fitote.2010.05.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Prostate cancer is the fifth most common neoplasm worldwide, and the second most common cancer among men. Ginsenosides, the main component of ginseng, have been known for their medicinal effects such as anti-inflammatory and anti-proliferative activities. In this study, we investigated the inhibitory effects of ginsenosides (ginsenoside 20(R)-Rh2 and ginsenoside 20 (S)-Rh2) on prostate cancer cells in vitro. Only ginsenoside 20(S)-Rh2 showed proliferation inhibition on androgen-dependent and -independent prostate cancer cells. These results implied that the stereochemistry of the hydroxyl group at C-20 may play an important role in antitumor activities. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：902 / 905

页数：4

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