The CD34-microvascular density in colorectal cancer patients

被引：0

作者：

Balac, I. ^{[1
]}

Jurisic, V. ^{[2
]}

Laban, A. ^{[3
]}

Randelovic, T. ^{[4
]}

Knezevic, P. ^{[1
]}

Pantic, I. ^{[5
]}

Dzodic, R. ^{[6
]}

机构：

[1] Clin Hosp Ctr Zemun, Dept Surg, Belgrade, Serbia

[2] Fac Med Belgrade, Inst Pathol, Kragujevac, Serbia

[3] Med Fac Kragujevac, Dept Pathophysiol, Kragujevac, Serbia

[4] Clin Hosp Ctr Bezanijska Kosa, Dept Surg, Belgrade, Serbia

[5] Fac Med Belgrade, Inst Physiol, Belgrade 11000, Serbia

[6] Inst Oncol & Radiol Serbia, Dept Surg, Belgrade, Serbia

来源：

JOURNAL OF BUON | 2012年 / 17卷 / 01期

关键词：

angiogenesis; CD34; colorectal cancer; microvascular density; survival; ENDOTHELIAL GROWTH-FACTOR; TUMOR ANGIOGENESIS; MICROVESSEL DENSITY; FACTOR EXPRESSION; CARCINOMA; METASTASIS; SURVIVAL; MODE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To investigate the influence of the angiogenesis parameter CD34 micro vascular density (MVD) on overall survival of colorectal cancer (CRC) patients. Methods: Thirty-one CRC patients were followed-up for 72 months after curative colorectal operation. Blood vessels measurement was done using the CD34-MVD immunochemistry method, and light microscopy Results: MVD was inversely correlated with patients' survival. MVD value < 35 proved as independent good prognostic factor, and patients with this value lived during the 72-month follow up after surgery, while a MVD value > 65 was an independent poor prognostic factor and such patients died within 11 months after radical surgery for CRC (p<0.01). Conclusion:According to these results, the CD34-MVD seems lobe a significant prognosticator of overall survival in CRC patients.

引用

页码：97 / 101

页数：5

共 16 条

[1] Association of vascular endothelial growth factor expression with tumor angiogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer [J].