Nanoparticle-based drug delivery systems for the treatment of cardiovascular diseases

被引：37
作者：
Yang, Fangyu [1 ]
Xue, Jianjiang [1 ]
Wang, Guixue [2 ]
Diao, Qizhi [3 ]
机构：
[1] Chongqing Med Univ, Univ Town Hosp, Dept Clin Lab Med, Chongqing, Peoples R China
[2] Bioengn Coll Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants, Minist Educ, Chongqing, Peoples R China
[3] Sanya Women & Childrens Hosp, Shanghai Childrens Med Ctr, Dept Clin Lab Med, Hainan, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
cardiovascular diseases; nanoparticles; drug delivery; nanomedicine; nanotoxicity; INCORPORATED NANOPARTICLES; OXIDATIVE STRESS; IN-VITRO; NANOMEDICINE; INFLAMMATION; PREVENTION; MONOCROTALINE; DIAGNOSIS; VESICLES; THERAPY;
D O I：
10.3389/fphar.2022.999404
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cardiovascular disease is the most common health problem worldwide and remains the leading cause of morbidity and mortality. Despite recent advances in the management of cardiovascular diseases, pharmaceutical treatment remains suboptimal because of poor pharmacokinetics and high toxicity. However, since being harnessed in the cancer field for the delivery of safer and more effective chemotherapeutics, nanoparticle-based drug delivery systems have offered multiple significant therapeutic effects in treating cardiovascular diseases. Nanoparticle-based drug delivery systems alter the biodistribution of therapeutic agents through site-specific, target-oriented delivery and controlled drug release of precise medicines. Metal-, lipid-, and polymer-based nanoparticles represent ideal materials for use in cardiovascular therapeutics. New developments in the therapeutic potential of drug delivery using nanoparticles and the application of nanomedicine to cardiovascular diseases are described in this review. Furthermore, this review discusses our current understanding of the potential role of nanoparticles in metabolism and toxicity after therapeutic action, with a view to providing a safer and more effective strategy for the treatment of cardiovascular disease.
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页数：14
相关论文
共 101 条
[51]   Site-Specific MicroRNA-33 Antagonism by pH-Responsive Nanotherapies for Treatment of Atherosclerosis via Regulating Cholesterol Efflux and Adaptive Immunity [J].
Li, Chenwen ;
Dou, Yin ;
Chen, Yidan ;
Qi, Yuantong ;
Li, Lanlan ;
Han, Songling ;
Jin, Taotao ;
Guo, Jiawei ;
Chen, Jianhong ;
Zhang, Jianxiang .
ADVANCED FUNCTIONAL MATERIALS, 2020, 30 (42)
[52]   Inflammation and atherosclerosis [J].
Libby, P ;
Ridker, PM ;
Maseri, A .
CIRCULATION, 2002, 105 (09) :1135-1143
[53]   Progress and challenges in translating the biology of atherosclerosis [J].
Libby, Peter ;
Ridker, Paul M. ;
Hansson, Goran K. .
NATURE, 2011, 473 (7347) :317-325
[54]   Hyaluronic acid-decorated reconstituted high density lipoprotein targeting atherosclerotic lesions [J].
Liu, Lisha ;
He, Hongliang ;
Zhang, Mengyuan ;
Zhang, Shuangshuang ;
Zhang, Wenli ;
Liu, Jianping .
BIOMATERIALS, 2014, 35 (27) :8002-8014
[55]   Perspectives and opportunities for nanomedicine in the management of atherosclerosis [J].
Lobatto, Mark E. ;
Fuster, Valentin ;
Fayad, Zahi A. ;
Mulder, Willem J. M. .
NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (11) :835-852
[56]   Multimodal Clinical Imaging To Longitudinally Assess a Nanomedical Anti-Inflammatory Treatment in Experimental Atherosclerosis [J].
Lobatto, Mark E. ;
Fayad, Zahi A. ;
Silvera, Stephane ;
Vucic, Esad ;
Calcagno, Claudia ;
Mani, Venkatesh ;
Dickson, Stephen D. ;
Nicolay, Klaas ;
Banciu, Manuela ;
Schiffelers, Raymond M. ;
Metselaar, Josbert M. ;
van Bloois, Louis ;
Wu, Hai-Shan ;
Fallon, John T. ;
Rudd, James H. ;
Fuster, Valentin ;
Fisher, Edward A. ;
Storm, Gert ;
Mulder, Willem J. M. .
MOLECULAR PHARMACEUTICS, 2010, 7 (06) :2020-2029
[57]   Nanotechnology-based electrochemical detection strategies for hypertension markers [J].
Madhurantakam, Sasya ;
Babu, K. Jayanth ;
Rayappan, John Bosco Balaguru ;
Krishnan, Uma Maheswari .
BIOSENSORS & BIOELECTRONICS, 2018, 116 :67-80
[58]  
Madigan Mariah, 2018, Bioengineering (Basel), V5, DOI 10.3390/bioengineering5020028
[59]   Role of Beta-blockers in Cardiovascular Disease in 2019 [J].
Martinez-Milla, Juan ;
Raposeiras-Roubin, Sergio ;
Pascual-Figal, Domingo A. ;
Ibanez, Borja .
REVISTA ESPANOLA DE CARDIOLOGIA, 2019, 72 (10) :844-852
[60]   Atherosclerosis Treatment with Stimuli-Responsive Nanoagents: Recent Advances and Future Perspectives [J].
Maruf, Ali ;
Wang, Yi ;
Yin, Tieyin ;
Huang, Junli ;
Wang, Nan ;
Durkan, Colm ;
Tan, Youhua ;
Wu, Wei ;
Wang, Guixue .
ADVANCED HEALTHCARE MATERIALS, 2019, 8 (11)
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