Mild Pd/Cu-Catalyzed Sila- Sonogashira Coupling of (Hetero)aryl Bromides with (Hetero)arylethynylsilanes under PTC Conditions

被引：28

作者：

Bellina, Fabio ^{[1
]}

Lessi, Marco ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

来源：

SYNLETT | 2012年 / 05期

关键词：

Sonogashira reaction; palladium; alkynylsilanes; diarylethynes; copper; phase-transfer catalysis; COPPER-FREE; ARYL IODIDES; AMBIENT CONDITIONS; ROOM-TEMPERATURE; TERMINAL ALKYNES; IONIC LIQUIDS; HECK REACTION; IN-SITU; ALKYNYLSILANES; WATER;

D O I：

10.1055/s-0031-1290601

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium/copper cocatalyzed sila-Sonogashira reaction of (hetero)arylethynysilanes with (hetero) aryl bromides in toluene and water at 40 degrees C under PTC conditions gave the required di(hetero)arylethynes in moderate to high yields. Activated, deactivated and ortho-substituted (hetero) aryl bromides are well tolerated. This protocol also allowed the preparation of symmetrical diarylethynes by double arylation of 1,2-bis(trimethylsilyl)ethyne.

引用

页码：773 / 777

页数：5

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