Synthesis of the functionally 4-substituted 1-methyl-3-thioxo-2,3,5,6,7,8-hexahydroisoquinolines by SNVin reaction of 2-acetyl-1-(N-morpholinyl)cyclohexene with malonothio(dithio)amides

被引：4

作者：

Dyachenko, I. V. ^{[1
]}

Vovk, M. V. ^{[2
]}

机构：

[1] Shevchenko Lugansk Natl Univ, UA-91011 Lugansk, Ukraine

[2] Natl Acad Sci Ukraine, Inst Organ Chem, Kiev, Ukraine

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2012年 / 82卷 / 02期

关键词：

Anhydrous Ethanol; Thioamide; Dithio; Sodium Ethoxide; EtONa;

D O I：

10.1134/S1070363212020156

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-Carbamoyl(thiocarbamoyl)-3-thioxo-2,3,5,6,7,8-hexahydroisoquinolines were synthesized by the S(N)Vin reaction of 2-acetyl-1-(N-morpholinyl)acetylcyclohexene with malonothio(dithio)amides. The cyclocondensation direction was confirmed with the X-ray diffraction analysis of 1-methyl-3-methylthio-5,6,7,8-tetrahydroisoquinoline-4-carboxamide.

引用

页码：251 / 255

页数：5

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