One-Pot Approach to Pyrido-4-phenanthridinones by Palladium-Catalyzed Annulation of 4-Quinolones with 2-Bromobenzyl Bromides

被引：5
作者：
Arasakumar, Thangaraj [1 ,2 ]
Shyamsivappan, Selvaraj [1 ]
Gopalan, Subashini [1 ]
Ata, Athar [2 ]
Mohan, Palathurai Subramaniam [1 ]
机构：
[1] Bharathiar Univ, Sch Chem Sci, Coimbatore 641046, Tamil Nadu, India
[2] Univ Winnipeg, Richardson Coll, Dept Chem, Environm Sci Complex,599 Portage Ave, Winnipeg, MB R3B 2G3, Canada
来源：
SYNLETT | 2019年 / 30卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
one-pot reaction; palladium catalysis; quinolones; phenanthridinones; polycyclic heterocycles; bromobenzyl bromides; H ACTIVATION; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; COUPLING REACTIONS; ARYLATION; PHENANTHRIDINONE; BENZAMIDES; INHIBITOR; ARENES; GROWTH;
D O I：
10.1055/s-0037-1610333
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A straightforward approach toward the assembly of phenanthridinone heterocycles has been developed through the palladium-catalyzed N-benzylation/intramolecular coupling reactions of readily prepared 4-quinolones with commercially available 2-bromobenzyl bromide derivatives. The target products were prepared in moderate to good yields, with tolerance of various functional groups.
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收藏
页码：63 / 68
页数：6
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