Endothelial LRP1-A Potential Target for the Treatment of Alzheimer's Disease

被引：2
|
作者：
Storck, Steffen E. [1 ]
Pietrzik, Claus U. [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Inst Pathobiochem, Mol Neurodegenerat, Univ Med Ctr, Duesbergweg 6, D-55099 Mainz, Germany
来源：
PHARMACEUTICAL RESEARCH | 2017年 / 34卷 / 12期
关键词：
Alzheimer's disease; angiopeps; beta-amyloid; blood-brain barrier; choroid plexus; drug delivery; LRP1; targeting; RECEPTOR-RELATED PROTEIN; BLOOD-BRAIN-BARRIER; AMYLOID PRECURSOR PROTEIN; CENTRAL-NERVOUS-SYSTEM; A-BETA OLIGOMERS; DRUG-DELIVERY; APOLIPOPROTEIN-E; IN-VITRO; CEREBROSPINAL-FLUID; POLYMERIC NANOPARTICLES;
D O I：
10.1007/s11095-017-2267-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The accumulation of the neurotoxin beta-amyloid (A beta) is a major hallmark in Alzheimer's disease (AD). A beta homeostasis in the brain is governed by its production and various clearance mechanisms. Both pathways are influenced by the ubiquitously expressed low-density lipoprotein receptor-related protein 1 (LRP1). In cerebral blood vessels, LRP1 is an important mediator for the rapid removal of A beta from brain via transport across the blood-brain barrier (BBB). Here, we summarize recent findings on LRP1 function and discuss the targeting of LRP1 as a modulator for AD pathology and drug delivery into the brain.
引用
收藏
页码：2637 / 2651
页数：15
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