A Novel Variant, NDM-5, of the New Delhi Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli ST648 Isolate Recovered from a Patient in the United Kingdom

被引：336

作者：

Hornsey, Michael ^{[1
]}

Phee, Lynette ^{[2
]}

Wareham, David W. ^{[1
,2
]}

机构：

[1] Queen Mary Univ London, Antimicrobial Res Grp, Ctr Immunol & Infect Dis, Blizard Inst,Barts & London Sch Med & Dent, London E1 2AT, England

[2] Barts & London NHS Trust, Div Infect, London, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 12期

关键词：

RAPID DETECTION; MULTIPLEX PCR; CARBAPENEMASES; ENTEROBACTERIACEAE;

D O I：

10.1128/AAC.05108-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A new variant of the New Delhi metallo-enzyme (NDM) carbapenemase was identified in a multidrug-resistant Escherichia coli ST648 isolate recovered from the perineum and throat of a patient in the United Kingdom with a recent history of hospitalization in India. NDM-5 differed from existing enzymes due to substitutions at positions 88 (Val -> Leu) and 154 (Met -> Leu) and reduced the susceptibility of E. coli TOP10 transformants to expanded-spectrum cephalosporins and carbapenems when expressed under its native promoter.

引用

收藏

页码：5952 / 5954

页数：3

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