SIMPLE AND SENSITIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF MESALAMINE IN BULK AND TABLET DOSAGE FORMS

被引：11

作者：

Chandra, Bala Sekaran ^{[1
]}

Bhogela, Siva Santhosh ^{[1
]}

Shaik, Manjusha ^{[1
]}

Vadlamudi, Chaitanya Sravanthi ^{[1
]}

Chappa, Meghana ^{[1
]}

Maddirala, Naga Sirisha ^{[1
]}

机构：

[1] JKC Coll, Dept Biotechnol, Guntur, Andhra Pradesh, India

来源：

QUIMICA NOVA | 2011年 / 34卷 / 06期

关键词：

mesalamine; spectrophotometric analysis; validation; LIQUID-CHROMATOGRAPHIC METHOD; ACTIVE ULCERATIVE-COLITIS; 5-AMINOSALICYLIC ACID; N-ACETYL-5-AMINOSALICYLIC ACID; MAJOR METABOLITES; VALIDATION; PHARMACOKINETICS; HPLC; SULFASALAZINE; IMPURITIES;

D O I：

10.1590/S0100-40422011000600026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three simple, sensitive, economical and reproducible spectrophotometric methods (A, B and C) are described for determination of mesalamine in pure drug as well as in tablet dosage forms. Method A is based on the reduction of tungstate and/or molybdate in Folin Ciocalteu's reagent; method B describes the reaction between the diazotized drug and alpha-naphthol and method C is based on the reaction of the drug with vanillin, in acidic medium. Under optimum conditions, mesalamine could be quantified in the concentration ranges, 1-30, 1-15 and 2-30 mu g mL(-1) by method A, B and C, respectively. All the methods have been applied to the determination of mesalamine in tablet dosage forms. Results of analysis are validated statistically.

引用

页码：1068 / 1073

页数：6

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