SIMPLE AND SENSITIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF MESALAMINE IN BULK AND TABLET DOSAGE FORMS

被引：11

作者：

Chandra, Bala Sekaran ^{[1
]}

Bhogela, Siva Santhosh ^{[1
]}

Shaik, Manjusha ^{[1
]}

Vadlamudi, Chaitanya Sravanthi ^{[1
]}

Chappa, Meghana ^{[1
]}

Maddirala, Naga Sirisha ^{[1
]}

机构：

[1] JKC Coll, Dept Biotechnol, Guntur, Andhra Pradesh, India

来源：

QUIMICA NOVA | 2011年 / 34卷 / 06期

关键词：

mesalamine; spectrophotometric analysis; validation; LIQUID-CHROMATOGRAPHIC METHOD; ACTIVE ULCERATIVE-COLITIS; 5-AMINOSALICYLIC ACID; N-ACETYL-5-AMINOSALICYLIC ACID; MAJOR METABOLITES; VALIDATION; PHARMACOKINETICS; HPLC; SULFASALAZINE; IMPURITIES;

D O I：

10.1590/S0100-40422011000600026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three simple, sensitive, economical and reproducible spectrophotometric methods (A, B and C) are described for determination of mesalamine in pure drug as well as in tablet dosage forms. Method A is based on the reduction of tungstate and/or molybdate in Folin Ciocalteu's reagent; method B describes the reaction between the diazotized drug and alpha-naphthol and method C is based on the reaction of the drug with vanillin, in acidic medium. Under optimum conditions, mesalamine could be quantified in the concentration ranges, 1-30, 1-15 and 2-30 mu g mL(-1) by method A, B and C, respectively. All the methods have been applied to the determination of mesalamine in tablet dosage forms. Results of analysis are validated statistically.

引用

页码：1068 / 1073

页数：6

共 50 条

[1] Development and Validation of Spectrophotometric Methods for the Estimation of Mesalamine in Tablet Dosage Forms
Patel, K. M.
Patel, C. N.
Panigrahi, B.
Parikh, A. S.
Patel, H. N.
JOURNAL OF YOUNG PHARMACISTS, 2010, 2 (03) : 284 - 288
[2] Spectrophotometric determination of nateglinide in bulk and tablet dosage forms
Jain, Suresh
Bhandari, Anil
Purohit, Suresh
ASIAN JOURNAL OF PHARMACEUTICS, 2009, 3 (03) : 218 - 221
[3] Simple spectrophotometric methods for the estimation of ofloxacin in dosage forms
Basu, S. K.
Krishnamoorthy, B.
ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (07) : 5223 - 5228
[4] Development and Validation of Spectrophotometric Method for Estimation of Cephalexin in Bulk and Tablet Dosage Forms
Vyas, A.
Shukla, S. S.
Patel, R.
Pandey, R.
Jain, V.
Singh, D.
Nagori, B. P.
ORIENTAL JOURNAL OF CHEMISTRY, 2011, 27 (01) : 359 - 362
[5] Spectrophotometric methods for the simultaneous estimation of doxycycline and tinidazole in tablet dosage forms
Daharwal, S. J.
Saraf, Swarnlata
Saraf, S.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2008, 42 (01) : 27 - 31
[6] Spectrophotometric methods for determination of ritodrine in bulk and in pharmaceutical dosage forms
El-Ghaffar, Mohamed Abd
El-Sherbiny, Dina
El-Wasseef, Dalia
El-Ashry, Saadia
JOURNAL OF FOOD AND DRUG ANALYSIS, 2008, 16 (02) : 26 - 35
[7] Spectrophotometric methods for the determination of letrozole in bulk and pharmaceutical dosage forms
Acharjya, Sasmita Kumari
Mallick, Priyambada
Panda, Pinakini
Kumar, K. Ravi
Annapurna, M. Mathrusri
JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH, 2010, 1 (03) : 348 - 353
[8] A Simple and Sensitive HPTLC Method for Simultaneous Analysis of Domperidone and Paracetamol in Tablet Dosage Forms
Alok Yadav
Raman M. Singh
Satish C. Mathur
Pawan K. Saini
Gyanendra N. Singh
JPC – Journal of Planar Chromatography – Modern TLC, 2009, 22 : 421 - 424
[9] A Simple and Sensitive HPTLC Method for Simultaneous Analysis of Domperidone and Paracetamol in Tablet Dosage Forms
Yadav, Alok
Singh, Raman M.
Mathur, Satish C.
Saini, Pawan K.
Singh, Gyanendra N.
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, 2009, 22 (06) : 421 - 424
[10] A Sensitive Kinetic Spectrophotometric Determination of Cefprozil and Dropropizine in Bulk and in Dosage Forms
Abdel-Gawad, Fatma M.
Mostafa, Carmen S.
Abdel-Hamid, Safaa M.
Abdel-Moaty, Mona M.
Abbas, Nagat A.
EGYPTIAN JOURNAL OF CHEMISTRY, 2010, 53 (05): : 631 - 643

← 1 2 3 4 5 →