Interaction of porphyrin with G-quadruplex structures

被引：12
|
作者：
Erra, E
Petraccone, L
Esposito, V
Randazzo, A
Mayol, L
Ladbury, J
Barone, G
Giancola, C [1 ]
机构：
[1] Univ Naples Federico 2, Dipartmento Chim, Naples, Italy
[2] Univ Salerno, Dipartimento Sci Farmaceut, Fisciano, SA, Italy
[3] UCL, Dept Biochem & Mol Biol, London, England
[4] Univ Naples Federico 2, Dipartimento Chim Sostanze Nat, Naples, Italy
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2005年 / 24卷 / 5-7期
关键词：
G-quadruplex; porphyrin; drug-DNA interactions; isothermal titration calorimetry;
D O I：
10.1081/NCN-200060070
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Isothermal titration calorimetry (ITC) is a sensitive technique for probing bimolecular processes and can provide direct information about the binding affinity and stoichiometry and the key thermodynamic parameters involved. ITC has been used to investigate the interaction of the ligand H(2)TMPyP to the two DNA quadruplexes, [d(AGGGT)](4) and [d(TGGGGT)](4). Analysis of the ITC data reveals that porphyrin/quadruplex binding stoichiometry under saturating conditions is 1:2 for [d(AGGGT)](4) and 2: 1 for [d(TGGGGT)](4), respectively.
引用
收藏
页码：753 / 756
页数：4
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