New and rapid Ultra-Performance Liquid Chromatography assay of paclitaxel

被引：5
作者：
Alvi, Khisal A. [1 ]
Wang, Songjie [1 ]
Tous, Guillermo [1 ]
机构：
[1] Phyton Biotech Inc, East Windsor, NJ 08520 USA
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2008年 / 31卷 / 07期
关键词：
paclitaxel; 10-deacetyl baccatin III; baccatin III; UPLC;
D O I：
10.1080/10826070801924402
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A new Ultra-Performance Liquid Chromatography (UPLC) method for assaying paclitaxel and related compounds in plant tissue cultures is described. The method has been shown to be rapid, economical, accurate, linear, precise, and specific, and can be used to assay bulk drug substance (BDS) and determine its chromatographic purity, as well as to assay paclitaxel in process and biomass samples.
引用
收藏
页码：941 / 949
页数：9
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