The role of sphingosine-1-phosphate and its receptors in asthma

被引：46

作者：

Ryan, John J. ^{[2
]}

Spiegel, Sarah ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, Dept Biochem & Mol Biol, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Sch Med, Dept Biol, Richmond, VA 23298 USA

来源：

DRUG NEWS & PERSPECTIVES | 2008年 / 21卷 / 02期

关键词：

D O I：

10.1358/dnp.2008.21.2.1188195

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that plays important roles in allergic responses, including asthma and anaphylaxis, the incidence of which is rising worldwide especially in industrialized urban populations. In this review, we will discuss how S1P is formed and released, and how it acts at many cellular levels, including mast cells, the airway epithelium, airway smooth muscle and many immune cells. Since the actions of S1P on all of these cells could exacerbate allergic responses, the proteins that synthesize, release and respond to S1P offer plausible targets for a new generation of antiinflammatory therapeutics. (C) 2008 Prous Science, S.A.U. or its licensors. All rights reserved.

引用

页码：89 / 96

页数：8

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