Mitochondria unite to survive

被引：47

作者：

Blackstone, Craig ^{[1
]}

Chang, Chuang-Rung ^{[2
,3
]}

机构：

[1] Natl Inst Neurol Disorders & Stroke, Neurogenet Branch, NIH, Bethesda, MD 20892 USA

[2] Natl Tsing Hua Univ, Inst Biotechnol, Hsinchu 30013, Taiwan

[3] Natl Tsing Hua Univ, Dept Life Sci, Hsinchu 30013, Taiwan

来源：

NATURE CELL BIOLOGY | 2011年 / 13卷 / 05期

关键词：

DEPENDENT PROTEIN-KINASE; DRP1; PHOSPHORYLATION; MITOPHAGY; FISSION; DEGRADATION; STARVATION; DEATH;

D O I：

10.1038/ncb0511-521

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Starvation of animals or cells triggers autophagic degradation of cell contents to retrieve nutrients, but, paradoxically, mitochondria enlarge. This is now shown to result from inhibition of mitochondrial fission through PKA-mediated phosphorylation of the GTPase DRP1. Elongation of mitochondria optimizes ATP production and spares them from autophagy-mediated destruction.

引用

页码：521 / 522

页数：2

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