Suppressive Effects of N-Acetyl-D-Glucosamine on Rheumatoid Arthritis Mouse Models

被引：36

作者：

Azuma, Kazuo ^{[1
]}

Osaki, Tomohiro ^{[1
]}

Wakuda, Takashi ^{[1
]}

Tsuka, Takeshi ^{[1
]}

Imagawa, Tomohiro ^{[1
]}

Okamoto, Yoshiharu ^{[1
]}

Minami, Saburo ^{[1
]}

机构：

[1] Dept Vet Clin Med, Tottori 6808553, Japan

来源：

INFLAMMATION | 2012年 / 35卷 / 04期

关键词：

N-acetyl-D-glucosamine; D-glucosamine hydrochloride; SKG/jcl mice; rheumatoid arthritis; REGULATORY T-CELLS; AUTOIMMUNE ARTHRITIS; MICE; ACETYLGLUCOSAMINE; CHONDROCYTES; ACTIVATION;

D O I：

10.1007/s10753-012-9459-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We examined effects of N-acetyl-d-glucosamine (GlcNAc) on rheumatoid arthritis (RA) mouse models and effects of GlcNAc and glucosamine hydrochloride (GlcN) on several serum cytokine productions in RA mouse models. SKG/jcl mice were divided into control, GlcNAc, and GlcN groups. For 56 days, the control group received normal food, the GlcNAc group received 0.5 % GlcNAc-containing food, and the GlcN group received 0.5 % GlcN-containing food. GlcNAc and GlcN equally suppressed arthritis scores and histopathological scores compared to the control group. In the GlcN group, serum tumor necrosis factor-alpha and interleukin (IL)-6 concentrations were significantly decreased compared to the control group. In the GlcNAc group, serum IL-10, transforming growth factor beta-1, and IL-2 concentrations were significantly increased compared to the control group. Our results indicated that GlcNAc also has suppressive effects on experimental RA in mouse models. The results of serum cytokine concentrations suggested that compared to GlcN, GlcNAc has a different suppressive mechanism in experimental RA models.

引用

页码：1462 / 1465

页数：4

共 14 条

[1] Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy [J].