CNS prophylaxis for diffuse large B-cell lymphoma

被引：2

作者：

Eyre, Toby A. ^{[1
,17
]}

Savage, Kerry J. ^{[2
]}

Cheah, Chan Y. ^{[3
,4
,5
]}

El-Galaly, Tarec C. ^{[6
,7
,8
]}

Lewis, Katharine L. ^{[3
,4
,5
]}

McKay, Pamela ^{[9
]}

Wilson, Matthew R. ^{[10
]}

Evens, Andrew M. ^{[11
,12
]}

Bobillo, Sabela ^{[13
]}

Villa, Diego ^{[2
]}

Maurer, Matthew J. ^{[14
]}

Cwynarski, Kate ^{[15
]}

Ferreri, Andres ^{[16
]}

机构：

[1] Oxford Univ Hosp NHS Fdn Trust, Churchill Hosp, Dept Haematol, Oxford, Oxfordshire, England

[2] Univ British Columbia, British Columbia Canc Ctr Lymphoid Canc, BC Canc, Vancouver, BC, Canada

[3] Sir Charles Gairdner Hosp, Dept Haematol, Perth, WA, Australia

[4] Univ Western Australia, Dept Haematol, Perth, WA, Australia

[5] Linear Clin Res, Perth, WA, Australia

[6] Aalborg Univ Hosp, Clin Canc Res Ctr, Dept Hematol, Aalborg, Denmark

[7] Aalborg Univ, Dept Clin Med, Aalborg, Denmark

[8] Odense Univ Hosp, Dept Hematol, Odense, Denmark

[9] Beatson West Scotland Canc Ctr, Glasgow, Scotland

[10] Queen Elizabeth Univ Hosp, Dept haematol, Glasgow, Scotland

[11] Rutgers Canc Inst New Jersey, Div Blood Disorders, New Brunswick, NJ USA

[12] Robert Wood Johnson Univ Hosp, Dept Med & Maternal Fetal Med, New Brunswick, NJ USA

[13] Vall dHebron Univ Hosp, Vall dHebron Inst Oncol VHIO, Dept Hematol, Barcelona, Spain

[14] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN USA

[15] Univ Coll London Hosp, Dept Haematol, London, England

[16] IRCCS San Raffaele Sci Inst, Dept Onco Haematol, Lymphoma Unit, Milan, Italy

[17] Oxford Univ Hosp NHSTrust, Dept Haematol, Oxford OXX3 7LE, Oxfordshire, England

来源：

LANCET ONCOLOGY | 2022年 / 23卷 / 09期

关键词：

CENTRAL-NERVOUS-SYSTEM; NON-HODGKINS-LYMPHOMA; HIGH-DOSE METHOTREXATE; INTRATHECAL METHOTREXATE; PROGNOSTIC-FACTORS; STANDARD CHOP; RISK-FACTORS; PHASE-III; R-CHOP; RITUXIMAB;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CNS relapse in the brain parenchyma, eyes, or leptomeninges is an uncommon but devastating complication of diffuse large B-cell lymphoma. CNS prophylaxis strategies, typically involving intrathecal or high-dose antimetabolites, have been developed in the front-line treatment setting with the aim to reduce this subsequent risk. Clinical and biological features associated with elevated risk are increasingly well defined and are discussed in this Review. This Review summarises both the historical and current developments in this challenging field, provides a nuanced discussion regarding current reasons for and against standard prophylactic measures, outlines evidence for the timing of prophylactic measures when delivered, and reflects on possible future developments.

引用

页码：E416 / E426

页数：11

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