Imatinib resistant BCR-ABL1 mutations at relapse in children with Ph plus ALL: a Children's Oncology Group (COG) study

被引:33
作者
Chang, Bill H. [1 ,2 ]
Willis, Stephanie G. [3 ]
Stork, Linda [1 ,2 ]
Hunger, Stephen P. [4 ]
Carroll, William L. [5 ]
Camitta, Bruce M. [6 ,7 ]
Winick, Naomi J. [8 ]
Druker, Brian J. [3 ,9 ]
Schultz, Kirk R. [10 ,11 ]
机构
[1] Oregon Hlth & Sci Univ, Dept Pediat, Div Pediat Hematol & Oncol, Portland, OR 97201 USA
[2] Oregon Hlth & Sci Univ, OHSU Knight Canc Inst, Portland, OR 97201 USA
[3] Oregon Hlth & Sci Univ, OHSU Knight Canc Inst, Div Hematol & Med Oncol, Portland, OR 97201 USA
[4] Univ Colorado, Sch Med, Childrens Hosp Colorado, Div Pediat Hematol,BMT, Aurora, CO USA
[5] NYU, Med Ctr, Inst Canc, New York, NY 10016 USA
[6] Childrens Hosp Wisconsin, Midwest Ctr Canc & Blood Disorders, Milwaukee, WI 53201 USA
[7] Med Coll Wisconsin, Milwaukee, WI 53226 USA
[8] Univ Texas SW Med Ctr Dallas, Dept Pediat Hematol Oncol, Dallas, TX 75390 USA
[9] Howard Hughes Med Ctr, Portland, OR USA
[10] Univ British Columbia, Pediat Hematol Oncol BMT, Vancouver, BC V5Z 1M9, Canada
[11] BC Childrens Hosp, Vancouver, BC, Canada
关键词
leukaemia; BCR-ABL1; mutations; childhood; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOID-LEUKEMIA; PHILADELPHIA-CHROMOSOME; KINASE; INHIBITORS; THERAPY;
D O I
10.1111/j.1365-2141.2012.09039.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:507 / 510
页数:4
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