Test-retest reliability of cerebral blood flow in healthy individuals using arterial spin labeling: Findings from the EMBARC study

被引：25

作者：

Almeida, Jorge R. C. ^{[1
,2
,12
]}

Greenberg, Tsafrir ^{[1
]}

Lu, Hanzhang ^{[3
]}

Chase, Henry W. ^{[1
]}

Fournier, Jay C. ^{[1
]}

Cooper, Crystal M. ^{[3
]}

Deckersbach, Thilo ^{[4
]}

Adams, Phil ^{[5
]}

Carmody, Thomas ^{[5
]}

Fava, Maurizio ^{[4
]}

Kurian, Benji ^{[3
]}

McGrath, Patrick J. ^{[6
,7
]}

McInnis, Melvin G. ^{[8
]}

Oquendo, Maria A. ^{[9
]}

Parsey, Ramin ^{[10
,11
]}

Weissman, Myrna ^{[6
,7
]}

Trivedi, Madhukar ^{[3
]}

Phillips, Mary L. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA

[2] Brown Univ, Sch Med, Dept Psychiat, Providence, RI 02906 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Dallas, TX 75235 USA

[4] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[5] Univ Texas Southwestern Med Ctr Dallas, Dept Clin Sci, Dallas, TX 75235 USA

[6] Columbia Univ Coll Phys & Surg, Dept Psychiat, 722 W 168th St, New York, NY 10032 USA

[7] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[8] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI 48109 USA

[9] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA

[10] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA

[11] SUNY Stony Brook, Dept Radiol, Stony Brook, NY 11794 USA

[12] Univ Texas Austin, Dell Med Sch, Dept Psychiat, 1701 Trinity St,Stop Z0600, Austin, TX 78712 USA

来源：

MAGNETIC RESONANCE IMAGING | 2018年 / 45卷

基金：

美国国家卫生研究院;

关键词：

Arterial spin labeling; Reliability; fMRI; Cerebral blood flow; MAJOR DEPRESSIVE DISORDER; POSITRON-EMISSION-TOMOGRAPHY; FUNCTIONAL CONNECTIVITY MRI; PERFUSION MRI; ANTIDEPRESSANT RESPONSE; CINGULATE CORTEX; ASL PERFUSION; BRAIN; REPRODUCIBILITY; OPTIMIZATION;

D O I：

10.1016/j.mri.2017.09.004

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Introduction: Previous investigations of test-retest reliability of cerebral blood flow (CBF) at rest measured with pseudo-continuous Arterial Spin Labeling (pCASL) demonstrated good reliability, but are limited by the use of similar scanner platforms. In the present study we examined test-retest reliability of CBF in regions implicated in emotion and the default mode network. Material and methods: We measured absolute and relative CBF at rest in thirty-one healthy subjects in two scan sessions, one week apart, at four different sites and three different scan platforms. We derived CBF from pCASL images with an automated algorithm and calculated infra-class correlation coefficients (ICCs) across sessions for regions of interest. In addition, we investigated site effects. Results: For both absolute and relative CBF measures, ICCs were good to excellent (i.e. > 0.6) in most brain regions, with highest values observed for the subgenual anterior cingulate cortex and ventral striatum. A leave one-site-out cross validation analysis did not show a significant effect for site on whole brain CBF and there was no proportional bias across sites. However, a significant site effect was present in the repeated measures ANOVA. Conclusions: The high test-retest reliability of CBF measured with pCASL in a range of brain regions implicated in emotion and salience processing, emotion regulation, and the default mode network, which have been previously linked to depression symptomatology supports its use in studies that aim to identify neuroimaging biomarkers of treatment response.

引用

页码：26 / 33

页数：8

共 63 条

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